TY - JOUR
T1 - Normative Pancreatic Stiffness Levels and Related Influences Established by Magnetic Resonance Elastography in Volunteers
AU - Xu, Youli
AU - Cai, Xiaoli
AU - Shi, Yu
AU - Yin, Meng
AU - Lan, Gongyu
AU - Zhang, Xianyi
AU - Ji, Ruoyun
AU - Chang, L.
N1 - Funding Information:
Grant Support: This project was funded by the National Natural Science Foundation of China (81771802 and 81771893), Support Program for Innovative Talents in Universities of Liaoning Province (LR2016020), and Foundation for the National Institutes of Health (grant EB001981). We thank Richard L. Ehman and Jun Chen of the Mayo Clinic for providing the MRE system and the tailored pancreatic MRE drivers.
Funding Information:
Grant Support: This project was funded by the National Natural Science Foundation of China (81771802 and 81771893), Support Program for Innovative Talents in Universities of Liaoning Province (LR2016020), and Foundation for the National Institutes of Health (grant EB001981). We thank Richard L. Ehman and Jun Chen of the Mayo Clinic for providing the MRE system and the tailored pancreatic MRE drivers.
Publisher Copyright:
© 2020 International Society for Magnetic Resonance in Medicine
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background: Large-scale normative studies of pancreatic stiffness and potential influences have yet to be pursued via magnetic resonance elastography (MRE). Purpose: To determine normative MRE-based pancreatic stiffness values and to examine related influential factors. Study Type: Prospective. Subjects: In all, 361 volunteers (men, 199; women, 162) with a median age of 54.0 years and a median body mass index (BMI) of 22.86 kg/m2 were prospectively recruited. Those with no histories of smoking, alcohol abuse, and diabetes mellitus (DM) were grouped as healthy volunteers, designating all others as positive controls. Field Strength/Sequence: Each volunteer underwent 3.0T pancreatic MRI at a frequency of 40 Hz. Assessment: Pancreatic stiffness values, pancreatic width and volume, waist circumference, and wave distance were measured in all subjects. Statistical Tests: Multiple linear regression analyses were performed to determine variables that influence MRE-determined stiffness. Results: The mean pancreatic stiffness in all volunteers was 1.20 ± 0.16 kPa. Stiffness levels in positive control volunteers proved significantly greater than levels in healthy volunteers (1.29 ± 0.17 kPa vs. 1.14 ± 0.13 kPa; P < 0.001). In multiple linear regression analysis, sex (P = 0.004), BMI (P < 0.001), pancreatic width (P = 0.005), smoking (P < 0.001), alcohol abuse (P < 0.001), and DM (P = 0.001) emerged as significant independent factors impacting pancreatic stiffness. Smoking, alcohol abuse, DM, and wide pancreas were associated with greater pancreatic stiffness (coefficients = 0.202, 0.183, 0.149, and 0.160, respectively), while reduced pancreatic stiffness corresponded with female sex and larger BMI (coefficient = −0.155 and −0.192, respectively). Data Conclusion: MRE-based pancreatic stiffness values are impacted by sex, BMI, pancreatic width, smoking, alcohol abuse, and DM. Reference values are essential for future clinical studies. Level of Evidence: 1. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2020;52:448–458.
AB - Background: Large-scale normative studies of pancreatic stiffness and potential influences have yet to be pursued via magnetic resonance elastography (MRE). Purpose: To determine normative MRE-based pancreatic stiffness values and to examine related influential factors. Study Type: Prospective. Subjects: In all, 361 volunteers (men, 199; women, 162) with a median age of 54.0 years and a median body mass index (BMI) of 22.86 kg/m2 were prospectively recruited. Those with no histories of smoking, alcohol abuse, and diabetes mellitus (DM) were grouped as healthy volunteers, designating all others as positive controls. Field Strength/Sequence: Each volunteer underwent 3.0T pancreatic MRI at a frequency of 40 Hz. Assessment: Pancreatic stiffness values, pancreatic width and volume, waist circumference, and wave distance were measured in all subjects. Statistical Tests: Multiple linear regression analyses were performed to determine variables that influence MRE-determined stiffness. Results: The mean pancreatic stiffness in all volunteers was 1.20 ± 0.16 kPa. Stiffness levels in positive control volunteers proved significantly greater than levels in healthy volunteers (1.29 ± 0.17 kPa vs. 1.14 ± 0.13 kPa; P < 0.001). In multiple linear regression analysis, sex (P = 0.004), BMI (P < 0.001), pancreatic width (P = 0.005), smoking (P < 0.001), alcohol abuse (P < 0.001), and DM (P = 0.001) emerged as significant independent factors impacting pancreatic stiffness. Smoking, alcohol abuse, DM, and wide pancreas were associated with greater pancreatic stiffness (coefficients = 0.202, 0.183, 0.149, and 0.160, respectively), while reduced pancreatic stiffness corresponded with female sex and larger BMI (coefficient = −0.155 and −0.192, respectively). Data Conclusion: MRE-based pancreatic stiffness values are impacted by sex, BMI, pancreatic width, smoking, alcohol abuse, and DM. Reference values are essential for future clinical studies. Level of Evidence: 1. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2020;52:448–458.
KW - alcohol
KW - magnetic resonance elastography
KW - pancreatic stiffness
KW - smoking
KW - volunteers
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U2 - 10.1002/jmri.27052
DO - 10.1002/jmri.27052
M3 - Article
C2 - 31943515
AN - SCOPUS:85077893748
SN - 1053-1807
VL - 52
SP - 448
EP - 458
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 2
ER -