TY - JOUR
T1 - Normative data for Aδ contact heat evoked potentials in adult population
T2 - A multicenter study
AU - Granovsky, Yelena
AU - Anand, Praveen
AU - Nakae, Aya
AU - Nascimento, Osvaldo
AU - Smith, Benn
AU - Sprecher, Elliot
AU - Valls-Solé, Josep
N1 - Publisher Copyright:
© 2016 International Association for the Study of Pain.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - There has been a significant increase over recent years in the use of contact heat evoked potentials (CHEPs) for the evaluation of small nerve fiber function. Measuring CHEP amplitude and latency has clinical utility for the diagnosis and assessment of conditions with neuropathic pain. This international multicenter study aimed to provide reference values for CHEPs to stimuli at 5 commonly examined body sites. Contact heat evoked potentials were recorded from 226 subjects (114 females), distributed per age decade between 20 and 79 years. Temperature stimuli were delivered by a thermode (32°C-51°C at a rate of 70°C/s). In phase I of the study, we investigated side-to-side differences and reported the maximum normal side-to-side difference in Aδ CHEP peak latency and amplitude for leg, forearm, and face. In phase II, we obtained normative data for 3 CHEP parameters (N 2 P 2 amplitude, N 2 latency, and P 2 latency), stratified for gender and age decades from face, upper and lower limbs, and overlying cervical and lumbar spine. In general, larger CHEP amplitudes were associated with higher evoked pain scores. Females had CHEPs of larger amplitude and shorter latency than males. This substantive data set of normative values will facilitate the clinical use of CHEPs as a rapid, noninvasive, and objective technique for the assessment of patients presenting with neuropathic pain.
AB - There has been a significant increase over recent years in the use of contact heat evoked potentials (CHEPs) for the evaluation of small nerve fiber function. Measuring CHEP amplitude and latency has clinical utility for the diagnosis and assessment of conditions with neuropathic pain. This international multicenter study aimed to provide reference values for CHEPs to stimuli at 5 commonly examined body sites. Contact heat evoked potentials were recorded from 226 subjects (114 females), distributed per age decade between 20 and 79 years. Temperature stimuli were delivered by a thermode (32°C-51°C at a rate of 70°C/s). In phase I of the study, we investigated side-to-side differences and reported the maximum normal side-to-side difference in Aδ CHEP peak latency and amplitude for leg, forearm, and face. In phase II, we obtained normative data for 3 CHEP parameters (N 2 P 2 amplitude, N 2 latency, and P 2 latency), stratified for gender and age decades from face, upper and lower limbs, and overlying cervical and lumbar spine. In general, larger CHEP amplitudes were associated with higher evoked pain scores. Females had CHEPs of larger amplitude and shorter latency than males. This substantive data set of normative values will facilitate the clinical use of CHEPs as a rapid, noninvasive, and objective technique for the assessment of patients presenting with neuropathic pain.
KW - CHEPs
KW - Nociceptive evoked potentials
KW - Normative data
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U2 - 10.1097/j.pain.0000000000000495
DO - 10.1097/j.pain.0000000000000495
M3 - Article
C2 - 26907092
AN - SCOPUS:84964720969
SN - 0304-3959
VL - 157
SP - 1156
EP - 1163
JO - Pain
JF - Pain
IS - 5
ER -