Normal left ventricular mechanical function and synchrony values by speckle-tracking echocardiography in the transplanted heart with normal ejection fraction

Haydar K. Saleh, Hector R Vilarraga, Garvan M Kane, Naveen Luke Pereira, Eugenia Raichlin, Yang Yu, Yuki Koshino, Sudhir S. Kushwaha, Fletcher A Jr. Miller, Jae Kuen Oh, Patricia Pellikka

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Abstract

Background: The purpose of this study was to describe the normal values for strain (S), systolic strain rate (SRs) and synchrony by speckle-tracking echocardiography (STE) in heart transplant (HTx) recipients who had normal left ventricular ejection fraction (LVEF) and no clinically significant complications. Methods: We evaluated S and SRs in 40 HTx patients at 1 year after transplant and 82 healthy controls with STE using velocity vector imaging. Results: Mean (SD) global longitudinal S and SRs, respectively, were lower in the transplant group compared with controls [-13.43% (2.39%) vs -17.28% (2.30%), p < 0.001; -0.83 (0.15) s-1 vs -0.96 (0.13) s-1, p < 0.001]. These variables were good for differentiating between groups: area under the curve was 0.88 for S and 0.73 for SRs. The differences remained significant after adjustment for other clinical variables. Global circumferential S and SRs were similar between groups. The standard deviation of the global longitudinal S time to peak of the 16 segments for HTx and control groups, respectively, was 41.67 (13.53) milliseconds vs 32.57 (12.81) milliseconds (p < 0.001). With 58.2 milliseconds as a cutoff value to define left ventricular synchrony, only 3 (8%) of the HTx patients and 4 (5%) of the control subjects were above that value (p = 0.6). Conclusion: To our knowledge, this is the first study describing normal values for S and SRs and synchrony by STE in a HTx population with normal LVEF: longitudinal S and SRs were reduced; circumferential deformation indexes were normal; and left ventricular synchrony was preserved.

Original languageEnglish (US)
Pages (from-to)652-658
Number of pages7
JournalJournal of Heart and Lung Transplantation
Volume30
Issue number6
DOIs
StatePublished - Jun 2011

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Left Ventricular Function
Echocardiography
Stroke Volume
Reference Values
Transplants
Area Under Curve
Control Groups
Population

Keywords

  • echocardiography
  • imaging
  • myocardial contraction
  • strain
  • transplantation

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

@article{bcef391acc3f4cb1bfb344d8d50f9f04,
title = "Normal left ventricular mechanical function and synchrony values by speckle-tracking echocardiography in the transplanted heart with normal ejection fraction",
abstract = "Background: The purpose of this study was to describe the normal values for strain (S), systolic strain rate (SRs) and synchrony by speckle-tracking echocardiography (STE) in heart transplant (HTx) recipients who had normal left ventricular ejection fraction (LVEF) and no clinically significant complications. Methods: We evaluated S and SRs in 40 HTx patients at 1 year after transplant and 82 healthy controls with STE using velocity vector imaging. Results: Mean (SD) global longitudinal S and SRs, respectively, were lower in the transplant group compared with controls [-13.43{\%} (2.39{\%}) vs -17.28{\%} (2.30{\%}), p < 0.001; -0.83 (0.15) s-1 vs -0.96 (0.13) s-1, p < 0.001]. These variables were good for differentiating between groups: area under the curve was 0.88 for S and 0.73 for SRs. The differences remained significant after adjustment for other clinical variables. Global circumferential S and SRs were similar between groups. The standard deviation of the global longitudinal S time to peak of the 16 segments for HTx and control groups, respectively, was 41.67 (13.53) milliseconds vs 32.57 (12.81) milliseconds (p < 0.001). With 58.2 milliseconds as a cutoff value to define left ventricular synchrony, only 3 (8{\%}) of the HTx patients and 4 (5{\%}) of the control subjects were above that value (p = 0.6). Conclusion: To our knowledge, this is the first study describing normal values for S and SRs and synchrony by STE in a HTx population with normal LVEF: longitudinal S and SRs were reduced; circumferential deformation indexes were normal; and left ventricular synchrony was preserved.",
keywords = "echocardiography, imaging, myocardial contraction, strain, transplantation",
author = "Saleh, {Haydar K.} and Vilarraga, {Hector R} and Kane, {Garvan M} and Pereira, {Naveen Luke} and Eugenia Raichlin and Yang Yu and Yuki Koshino and Kushwaha, {Sudhir S.} and Miller, {Fletcher A Jr.} and Oh, {Jae Kuen} and Patricia Pellikka",
year = "2011",
month = "6",
doi = "10.1016/j.healun.2010.12.004",
language = "English (US)",
volume = "30",
pages = "652--658",
journal = "Journal of Heart and Lung Transplantation",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "6",

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TY - JOUR

T1 - Normal left ventricular mechanical function and synchrony values by speckle-tracking echocardiography in the transplanted heart with normal ejection fraction

AU - Saleh, Haydar K.

AU - Vilarraga, Hector R

AU - Kane, Garvan M

AU - Pereira, Naveen Luke

AU - Raichlin, Eugenia

AU - Yu, Yang

AU - Koshino, Yuki

AU - Kushwaha, Sudhir S.

AU - Miller, Fletcher A Jr.

AU - Oh, Jae Kuen

AU - Pellikka, Patricia

PY - 2011/6

Y1 - 2011/6

N2 - Background: The purpose of this study was to describe the normal values for strain (S), systolic strain rate (SRs) and synchrony by speckle-tracking echocardiography (STE) in heart transplant (HTx) recipients who had normal left ventricular ejection fraction (LVEF) and no clinically significant complications. Methods: We evaluated S and SRs in 40 HTx patients at 1 year after transplant and 82 healthy controls with STE using velocity vector imaging. Results: Mean (SD) global longitudinal S and SRs, respectively, were lower in the transplant group compared with controls [-13.43% (2.39%) vs -17.28% (2.30%), p < 0.001; -0.83 (0.15) s-1 vs -0.96 (0.13) s-1, p < 0.001]. These variables were good for differentiating between groups: area under the curve was 0.88 for S and 0.73 for SRs. The differences remained significant after adjustment for other clinical variables. Global circumferential S and SRs were similar between groups. The standard deviation of the global longitudinal S time to peak of the 16 segments for HTx and control groups, respectively, was 41.67 (13.53) milliseconds vs 32.57 (12.81) milliseconds (p < 0.001). With 58.2 milliseconds as a cutoff value to define left ventricular synchrony, only 3 (8%) of the HTx patients and 4 (5%) of the control subjects were above that value (p = 0.6). Conclusion: To our knowledge, this is the first study describing normal values for S and SRs and synchrony by STE in a HTx population with normal LVEF: longitudinal S and SRs were reduced; circumferential deformation indexes were normal; and left ventricular synchrony was preserved.

AB - Background: The purpose of this study was to describe the normal values for strain (S), systolic strain rate (SRs) and synchrony by speckle-tracking echocardiography (STE) in heart transplant (HTx) recipients who had normal left ventricular ejection fraction (LVEF) and no clinically significant complications. Methods: We evaluated S and SRs in 40 HTx patients at 1 year after transplant and 82 healthy controls with STE using velocity vector imaging. Results: Mean (SD) global longitudinal S and SRs, respectively, were lower in the transplant group compared with controls [-13.43% (2.39%) vs -17.28% (2.30%), p < 0.001; -0.83 (0.15) s-1 vs -0.96 (0.13) s-1, p < 0.001]. These variables were good for differentiating between groups: area under the curve was 0.88 for S and 0.73 for SRs. The differences remained significant after adjustment for other clinical variables. Global circumferential S and SRs were similar between groups. The standard deviation of the global longitudinal S time to peak of the 16 segments for HTx and control groups, respectively, was 41.67 (13.53) milliseconds vs 32.57 (12.81) milliseconds (p < 0.001). With 58.2 milliseconds as a cutoff value to define left ventricular synchrony, only 3 (8%) of the HTx patients and 4 (5%) of the control subjects were above that value (p = 0.6). Conclusion: To our knowledge, this is the first study describing normal values for S and SRs and synchrony by STE in a HTx population with normal LVEF: longitudinal S and SRs were reduced; circumferential deformation indexes were normal; and left ventricular synchrony was preserved.

KW - echocardiography

KW - imaging

KW - myocardial contraction

KW - strain

KW - transplantation

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