Nonsystemic vasculitic neuropathy

Peter J Dyck, T. J. Benstead, D. L. Conn, J. C. Stevens, Anthony John Windebank, Phillip Anson Low

Research output: Contribution to journalArticle

269 Citations (Scopus)

Abstract

Among 65 patients with necrotizing vasculitis, 45 had systemic and 20 had nonsystemic vasculitis neuropathy. In nonsystemic vasculitic neuropathy, clinically only nerves are affected; there are no, or few, constitutional symptoms or serological abnormalities. The clinical and pathological features are those of an ischaemic neuropathy caused by a necrotizing vasculitis of small arterioles. These 20 patients had neuropathic symptoms for a median time of 11.5 yrs (range 1-35 yrs). The clinical pattern of neuropathy was that of multiple mononeuropathy in 13, asymmetric neuropathy in 4, distal polyneuropathy in 3, and sensory polyneuropathy in 1. As compared with their initial evaluation, 8 are now worse, 5 are better, 4 are approximately the same, and 3 are dead from unrelated causes. Prednisone was thought to prevent the development of new lesions in some cases. By contrast, of the 41 patients with systemic necrotizing vasculitis whose outcome is known, 12 are dead (median time, 1.5 yrs, range 3 months-8 yrs) and 29 are alive (median time, 6 yrs, range 6 months-22 yrs).

Original languageEnglish (US)
Pages (from-to)843-854
Number of pages12
JournalBrain
Volume110
Issue number4
StatePublished - 1987

Fingerprint

Vasculitis
peripheral nervous system diseases
vasculitis
Polyneuropathies
Mononeuropathies
Systemic Vasculitis
signs and symptoms (animals and humans)
Arterioles
Range of data
Prednisone
prednisone
Nerve
lesions (animal)
nerve tissue
Median
Evaluation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Dyck, P. J., Benstead, T. J., Conn, D. L., Stevens, J. C., Windebank, A. J., & Low, P. A. (1987). Nonsystemic vasculitic neuropathy. Brain, 110(4), 843-854.

Nonsystemic vasculitic neuropathy. / Dyck, Peter J; Benstead, T. J.; Conn, D. L.; Stevens, J. C.; Windebank, Anthony John; Low, Phillip Anson.

In: Brain, Vol. 110, No. 4, 1987, p. 843-854.

Research output: Contribution to journalArticle

Dyck, PJ, Benstead, TJ, Conn, DL, Stevens, JC, Windebank, AJ & Low, PA 1987, 'Nonsystemic vasculitic neuropathy', Brain, vol. 110, no. 4, pp. 843-854.
Dyck PJ, Benstead TJ, Conn DL, Stevens JC, Windebank AJ, Low PA. Nonsystemic vasculitic neuropathy. Brain. 1987;110(4):843-854.
Dyck, Peter J ; Benstead, T. J. ; Conn, D. L. ; Stevens, J. C. ; Windebank, Anthony John ; Low, Phillip Anson. / Nonsystemic vasculitic neuropathy. In: Brain. 1987 ; Vol. 110, No. 4. pp. 843-854.
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