Nonsteroidal anti-inflammatory drug-induced hepatoxicity

Alberto Unzueta, Hugo E Vargas

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Nonsteroidal anti-inflammatory drugs are among the most prescribed medications worldwide. After antibiotics and anticonvulsants they are considered the most common medications associated with drug-induced liver injury mainly through an idiosyncratic form of hepatotoxicity. In rare cases severe hepatotoxicity has been described with significant morbidity and mortality. Genetic risk factors have been reported with diclofenac and lumiracoxib. Postmarketing surveillance and monitoring is crucial to identify severe cases of hepatotoxicity.

Original languageEnglish (US)
Pages (from-to)643-656
Number of pages14
JournalClinics in Liver Disease
Volume17
Issue number4
DOIs
StatePublished - Nov 2013

Fingerprint

Chemical and Drug Induced Liver Injury
Diclofenac
Anticonvulsants
Anti-Inflammatory Agents
Anti-Bacterial Agents
Morbidity
Mortality
Pharmaceutical Preparations
lumiracoxib

Keywords

  • Acute liver injury
  • Drug safety
  • Drug surveillance
  • Drug-induced liver injury
  • Hy's law
  • Idiosyncratic hepatotoxicity
  • Liver transplantation
  • Nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Hepatology

Cite this

Nonsteroidal anti-inflammatory drug-induced hepatoxicity. / Unzueta, Alberto; Vargas, Hugo E.

In: Clinics in Liver Disease, Vol. 17, No. 4, 11.2013, p. 643-656.

Research output: Contribution to journalArticle

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