Nonsteroidal anti-inflammatory drug-induced hepatoxicity

Alberto Unzueta; Hugo E. Vargas

doi:10.1016/j.cld.2013.07.009

Nonsteroidal anti-inflammatory drug-induced hepatoxicity

Alberto Unzueta, Hugo E. Vargas

Hepatology

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Nonsteroidal anti-inflammatory drugs are among the most prescribed medications worldwide. After antibiotics and anticonvulsants they are considered the most common medications associated with drug-induced liver injury mainly through an idiosyncratic form of hepatotoxicity. In rare cases severe hepatotoxicity has been described with significant morbidity and mortality. Genetic risk factors have been reported with diclofenac and lumiracoxib. Postmarketing surveillance and monitoring is crucial to identify severe cases of hepatotoxicity.

Original language	English (US)
Pages (from-to)	643-656
Number of pages	14
Journal	Clinics in liver disease
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.cld.2013.07.009
State	Published - Nov 2013

Keywords

Acute liver injury
Drug safety
Drug surveillance
Drug-induced liver injury
Hy's law
Idiosyncratic hepatotoxicity
Liver transplantation
Nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

Hepatology

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10.1016/j.cld.2013.07.009

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title = "Nonsteroidal anti-inflammatory drug-induced hepatoxicity",

abstract = "Nonsteroidal anti-inflammatory drugs are among the most prescribed medications worldwide. After antibiotics and anticonvulsants they are considered the most common medications associated with drug-induced liver injury mainly through an idiosyncratic form of hepatotoxicity. In rare cases severe hepatotoxicity has been described with significant morbidity and mortality. Genetic risk factors have been reported with diclofenac and lumiracoxib. Postmarketing surveillance and monitoring is crucial to identify severe cases of hepatotoxicity.",

keywords = "Acute liver injury, Drug safety, Drug surveillance, Drug-induced liver injury, Hy's law, Idiosyncratic hepatotoxicity, Liver transplantation, Nonsteroidal anti-inflammatory drugs",

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AU - Vargas, Hugo E.

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AB - Nonsteroidal anti-inflammatory drugs are among the most prescribed medications worldwide. After antibiotics and anticonvulsants they are considered the most common medications associated with drug-induced liver injury mainly through an idiosyncratic form of hepatotoxicity. In rare cases severe hepatotoxicity has been described with significant morbidity and mortality. Genetic risk factors have been reported with diclofenac and lumiracoxib. Postmarketing surveillance and monitoring is crucial to identify severe cases of hepatotoxicity.

KW - Acute liver injury

KW - Drug safety

KW - Drug surveillance

KW - Drug-induced liver injury

KW - Hy's law

KW - Idiosyncratic hepatotoxicity

KW - Liver transplantation

KW - Nonsteroidal anti-inflammatory drugs

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Nonsteroidal anti-inflammatory drug-induced hepatoxicity

Abstract

Keywords

ASJC Scopus subject areas

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