TY - JOUR
T1 - Nonspecific interstitial pneumonia
T2 - Prognostic significance of high-resolution computed tomography in 59 patients
AU - Hozumi, Hironao
AU - Nakamura, Yutaro
AU - Johkoh, Takeshi
AU - Sumikawa, Hiromitsu
AU - Colby, Thomas V.
AU - Karayama, Masato
AU - Hayakawa, Hiroshi
AU - Yokomura, Koushi
AU - Imokawa, Shiro
AU - Yasuda, Kazumasa
AU - Toyoshima, Mikio
AU - Suganuma, Hideki
AU - Shirai, Toshihiro
AU - Inui, Naoki
AU - Suda, Takafumi
AU - Nakamura, Hirotoshi
AU - Chida, Kingo
PY - 2011/9
Y1 - 2011/9
N2 - Objective: To retrospectively analyze the prognostic implications of high-resolution computed tomography (HRCT) findings for patients with biopsy-proven nonspecific interstitial pneumonia (NSIP). Methods: Fifty-nine patients with NSIP (25 idiopathic NSIP, 34 collagen-vascular disease-associated NSIP) were included. Two chest radiologists independently evaluated the extent, presence, and distribution of various HRCT findings. Cox hazards analysis was used to evaluate the relationship between HRCT findings and prognosis. Results: The 5-year survival rate was 83% and the 10-year survival rate was 66%. Univariate analysis revealed that the extent of areas with ground-glass attenuation without traction bronchi-bronchiolectasis and that of airs-pace consolidation were associated with favorable outcome, whereas that of intralobular reticular opacities was associated with worse prognosis. Multivariate analysis showed that the extent of air-space consolidation was an independent factor of favorable outcome. Conclusion: In NSIP, the extent of areas with ground-glass attenuation without traction bronchi-bronchiolectasis, air-space consolidation, and intralobular reticular opacities correlate with survival.
AB - Objective: To retrospectively analyze the prognostic implications of high-resolution computed tomography (HRCT) findings for patients with biopsy-proven nonspecific interstitial pneumonia (NSIP). Methods: Fifty-nine patients with NSIP (25 idiopathic NSIP, 34 collagen-vascular disease-associated NSIP) were included. Two chest radiologists independently evaluated the extent, presence, and distribution of various HRCT findings. Cox hazards analysis was used to evaluate the relationship between HRCT findings and prognosis. Results: The 5-year survival rate was 83% and the 10-year survival rate was 66%. Univariate analysis revealed that the extent of areas with ground-glass attenuation without traction bronchi-bronchiolectasis and that of airs-pace consolidation were associated with favorable outcome, whereas that of intralobular reticular opacities was associated with worse prognosis. Multivariate analysis showed that the extent of air-space consolidation was an independent factor of favorable outcome. Conclusion: In NSIP, the extent of areas with ground-glass attenuation without traction bronchi-bronchiolectasis, air-space consolidation, and intralobular reticular opacities correlate with survival.
KW - high resolution computed tomography
KW - interstitial pneumonia
KW - nonspecific interstitial pneumonia
KW - prognosis
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U2 - 10.1097/RCT.0b013e31822a5883
DO - 10.1097/RCT.0b013e31822a5883
M3 - Article
C2 - 21926853
AN - SCOPUS:80053004740
VL - 35
SP - 583
EP - 589
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 5
ER -