Nonspecific interstitial pneumonia: Prognostic significance of high-resolution computed tomography in 59 patients

Hironao Hozumi, Yutaro Nakamura, Takeshi Johkoh, Hiromitsu Sumikawa, Thomas V. Colby, Masato Karayama, Hiroshi Hayakawa, Koushi Yokomura, Shiro Imokawa, Kazumasa Yasuda, Mikio Toyoshima, Hideki Suganuma, Toshihiro Shirai, Naoki Inui, Takafumi Suda, Hirotoshi Nakamura, Kingo Chida

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To retrospectively analyze the prognostic implications of high-resolution computed tomography (HRCT) findings for patients with biopsy-proven nonspecific interstitial pneumonia (NSIP). Methods: Fifty-nine patients with NSIP (25 idiopathic NSIP, 34 collagen-vascular disease-associated NSIP) were included. Two chest radiologists independently evaluated the extent, presence, and distribution of various HRCT findings. Cox hazards analysis was used to evaluate the relationship between HRCT findings and prognosis. Results: The 5-year survival rate was 83% and the 10-year survival rate was 66%. Univariate analysis revealed that the extent of areas with ground-glass attenuation without traction bronchi-bronchiolectasis and that of airs-pace consolidation were associated with favorable outcome, whereas that of intralobular reticular opacities was associated with worse prognosis. Multivariate analysis showed that the extent of air-space consolidation was an independent factor of favorable outcome. Conclusion: In NSIP, the extent of areas with ground-glass attenuation without traction bronchi-bronchiolectasis, air-space consolidation, and intralobular reticular opacities correlate with survival.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume35
Issue number5
DOIs
StatePublished - Sep 2011

Fingerprint

Interstitial Lung Diseases
Tomography
Air
Traction
Bronchi
Glass
Survival Rate
Idiopathic Interstitial Pneumonias
Collagen Diseases
Vascular Diseases
Thorax
Multivariate Analysis
Biopsy
Survival

Keywords

  • high resolution computed tomography
  • interstitial pneumonia
  • nonspecific interstitial pneumonia
  • prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Nonspecific interstitial pneumonia : Prognostic significance of high-resolution computed tomography in 59 patients. / Hozumi, Hironao; Nakamura, Yutaro; Johkoh, Takeshi; Sumikawa, Hiromitsu; Colby, Thomas V.; Karayama, Masato; Hayakawa, Hiroshi; Yokomura, Koushi; Imokawa, Shiro; Yasuda, Kazumasa; Toyoshima, Mikio; Suganuma, Hideki; Shirai, Toshihiro; Inui, Naoki; Suda, Takafumi; Nakamura, Hirotoshi; Chida, Kingo.

In: Journal of Computer Assisted Tomography, Vol. 35, No. 5, 09.2011, p. 583-589.

Research output: Contribution to journalArticle

Hozumi, H, Nakamura, Y, Johkoh, T, Sumikawa, H, Colby, TV, Karayama, M, Hayakawa, H, Yokomura, K, Imokawa, S, Yasuda, K, Toyoshima, M, Suganuma, H, Shirai, T, Inui, N, Suda, T, Nakamura, H & Chida, K 2011, 'Nonspecific interstitial pneumonia: Prognostic significance of high-resolution computed tomography in 59 patients', Journal of Computer Assisted Tomography, vol. 35, no. 5, pp. 583-589. https://doi.org/10.1097/RCT.0b013e31822a5883
Hozumi, Hironao ; Nakamura, Yutaro ; Johkoh, Takeshi ; Sumikawa, Hiromitsu ; Colby, Thomas V. ; Karayama, Masato ; Hayakawa, Hiroshi ; Yokomura, Koushi ; Imokawa, Shiro ; Yasuda, Kazumasa ; Toyoshima, Mikio ; Suganuma, Hideki ; Shirai, Toshihiro ; Inui, Naoki ; Suda, Takafumi ; Nakamura, Hirotoshi ; Chida, Kingo. / Nonspecific interstitial pneumonia : Prognostic significance of high-resolution computed tomography in 59 patients. In: Journal of Computer Assisted Tomography. 2011 ; Vol. 35, No. 5. pp. 583-589.
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