Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease

Masato Kono, Yutaro Nakamura, Katsuhiro Yoshimura, Yasunori Enomoto, Yoshiyuki Oyama, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Etsuko Hamada, Thomas V. Colby, Masato Maekawa, Takafumi Suda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background The aim of this study was to evaluate the incidence and clinical features of patients who developed collagen vascular disease (CVD) after an initial diagnosis of idiopathic nonspecific interstitial pneumonia (NSIP). Methods We conducted a retrospective review of 72 consecutive patients with NSIP who were diagnosed by surgical lung biopsy in our institution (idiopathic NSIP, n = 35; CVD-NSIP, n = 37 at initial diagnosis). No patients fulfilled the American College of Rheumatology criteria for a diagnosis with CVD within six months after the diagnosis of idiopathic NSIP. Results Of 35 patients initially diagnosed with idiopathic NSIP, six patients (17.1%) developed CVD during the follow-up period (5.5 ± 5.0 years); three patients were diagnosed with dermatomyositis (DM), two patients with overlap syndrome (DM and Sjogren's syndrome), and one patient with rheumatoid arthritis. The mean time until CVD diagnosis was 2.0 years (six months - 3.5 years), and the one-, two- and three-year incidences of CVD development were 3.6%, 15.2% and 20.0%, respectively. There was no significant difference in clinical characteristics and survival among patients with NSIP preceding CVD diagnosis, those with idiopathic NSIP, or those with CVD-NSIP. In addition, at the time of initial diagnosis, there was no significant difference for the fulfillment of previous criteria such as interstitial pneumonia with autoimmune feature (IPAF) between patients with NSIP preceding CVD diagnosis and those with idiopathic NSIP. Conclusions It is difficult to predict CVD occurrence and careful attention is needed to detect the development of CVD in patients with idiopathic NSIP.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalRespiratory Medicine
Volume117
DOIs
StatePublished - Aug 1 2016

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Collagen Diseases
Interstitial Lung Diseases
Vascular Diseases
Idiopathic Interstitial Pneumonias
Dermatomyositis
Sjogren's Syndrome
Incidence
Rheumatoid Arthritis

Keywords

  • Collagen vascular disease (CVD)
  • Connective tissue disease (CTD)
  • Idiopathic interstitial pneumonias (IIPs)
  • Interstitial pneumonia with autoimmune features (IPAF)
  • Nonspecific interstitial pneumonia (NSIP)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Kono, M., Nakamura, Y., Yoshimura, K., Enomoto, Y., Oyama, Y., Hozumi, H., ... Suda, T. (2016). Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease. Respiratory Medicine, 117, 40-47. https://doi.org/10.1016/j.rmed.2016.05.030

Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease. / Kono, Masato; Nakamura, Yutaro; Yoshimura, Katsuhiro; Enomoto, Yasunori; Oyama, Yoshiyuki; Hozumi, Hironao; Enomoto, Noriyuki; Fujisawa, Tomoyuki; Inui, Naoki; Hamada, Etsuko; Colby, Thomas V.; Maekawa, Masato; Suda, Takafumi.

In: Respiratory Medicine, Vol. 117, 01.08.2016, p. 40-47.

Research output: Contribution to journalArticle

Kono, M, Nakamura, Y, Yoshimura, K, Enomoto, Y, Oyama, Y, Hozumi, H, Enomoto, N, Fujisawa, T, Inui, N, Hamada, E, Colby, TV, Maekawa, M & Suda, T 2016, 'Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease', Respiratory Medicine, vol. 117, pp. 40-47. https://doi.org/10.1016/j.rmed.2016.05.030
Kono, Masato ; Nakamura, Yutaro ; Yoshimura, Katsuhiro ; Enomoto, Yasunori ; Oyama, Yoshiyuki ; Hozumi, Hironao ; Enomoto, Noriyuki ; Fujisawa, Tomoyuki ; Inui, Naoki ; Hamada, Etsuko ; Colby, Thomas V. ; Maekawa, Masato ; Suda, Takafumi. / Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease. In: Respiratory Medicine. 2016 ; Vol. 117. pp. 40-47.
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abstract = "Background The aim of this study was to evaluate the incidence and clinical features of patients who developed collagen vascular disease (CVD) after an initial diagnosis of idiopathic nonspecific interstitial pneumonia (NSIP). Methods We conducted a retrospective review of 72 consecutive patients with NSIP who were diagnosed by surgical lung biopsy in our institution (idiopathic NSIP, n = 35; CVD-NSIP, n = 37 at initial diagnosis). No patients fulfilled the American College of Rheumatology criteria for a diagnosis with CVD within six months after the diagnosis of idiopathic NSIP. Results Of 35 patients initially diagnosed with idiopathic NSIP, six patients (17.1{\%}) developed CVD during the follow-up period (5.5 ± 5.0 years); three patients were diagnosed with dermatomyositis (DM), two patients with overlap syndrome (DM and Sjogren's syndrome), and one patient with rheumatoid arthritis. The mean time until CVD diagnosis was 2.0 years (six months - 3.5 years), and the one-, two- and three-year incidences of CVD development were 3.6{\%}, 15.2{\%} and 20.0{\%}, respectively. There was no significant difference in clinical characteristics and survival among patients with NSIP preceding CVD diagnosis, those with idiopathic NSIP, or those with CVD-NSIP. In addition, at the time of initial diagnosis, there was no significant difference for the fulfillment of previous criteria such as interstitial pneumonia with autoimmune feature (IPAF) between patients with NSIP preceding CVD diagnosis and those with idiopathic NSIP. Conclusions It is difficult to predict CVD occurrence and careful attention is needed to detect the development of CVD in patients with idiopathic NSIP.",
keywords = "Collagen vascular disease (CVD), Connective tissue disease (CTD), Idiopathic interstitial pneumonias (IIPs), Interstitial pneumonia with autoimmune features (IPAF), Nonspecific interstitial pneumonia (NSIP)",
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T1 - Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease

AU - Kono, Masato

AU - Nakamura, Yutaro

AU - Yoshimura, Katsuhiro

AU - Enomoto, Yasunori

AU - Oyama, Yoshiyuki

AU - Hozumi, Hironao

AU - Enomoto, Noriyuki

AU - Fujisawa, Tomoyuki

AU - Inui, Naoki

AU - Hamada, Etsuko

AU - Colby, Thomas V.

AU - Maekawa, Masato

AU - Suda, Takafumi

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background The aim of this study was to evaluate the incidence and clinical features of patients who developed collagen vascular disease (CVD) after an initial diagnosis of idiopathic nonspecific interstitial pneumonia (NSIP). Methods We conducted a retrospective review of 72 consecutive patients with NSIP who were diagnosed by surgical lung biopsy in our institution (idiopathic NSIP, n = 35; CVD-NSIP, n = 37 at initial diagnosis). No patients fulfilled the American College of Rheumatology criteria for a diagnosis with CVD within six months after the diagnosis of idiopathic NSIP. Results Of 35 patients initially diagnosed with idiopathic NSIP, six patients (17.1%) developed CVD during the follow-up period (5.5 ± 5.0 years); three patients were diagnosed with dermatomyositis (DM), two patients with overlap syndrome (DM and Sjogren's syndrome), and one patient with rheumatoid arthritis. The mean time until CVD diagnosis was 2.0 years (six months - 3.5 years), and the one-, two- and three-year incidences of CVD development were 3.6%, 15.2% and 20.0%, respectively. There was no significant difference in clinical characteristics and survival among patients with NSIP preceding CVD diagnosis, those with idiopathic NSIP, or those with CVD-NSIP. In addition, at the time of initial diagnosis, there was no significant difference for the fulfillment of previous criteria such as interstitial pneumonia with autoimmune feature (IPAF) between patients with NSIP preceding CVD diagnosis and those with idiopathic NSIP. Conclusions It is difficult to predict CVD occurrence and careful attention is needed to detect the development of CVD in patients with idiopathic NSIP.

AB - Background The aim of this study was to evaluate the incidence and clinical features of patients who developed collagen vascular disease (CVD) after an initial diagnosis of idiopathic nonspecific interstitial pneumonia (NSIP). Methods We conducted a retrospective review of 72 consecutive patients with NSIP who were diagnosed by surgical lung biopsy in our institution (idiopathic NSIP, n = 35; CVD-NSIP, n = 37 at initial diagnosis). No patients fulfilled the American College of Rheumatology criteria for a diagnosis with CVD within six months after the diagnosis of idiopathic NSIP. Results Of 35 patients initially diagnosed with idiopathic NSIP, six patients (17.1%) developed CVD during the follow-up period (5.5 ± 5.0 years); three patients were diagnosed with dermatomyositis (DM), two patients with overlap syndrome (DM and Sjogren's syndrome), and one patient with rheumatoid arthritis. The mean time until CVD diagnosis was 2.0 years (six months - 3.5 years), and the one-, two- and three-year incidences of CVD development were 3.6%, 15.2% and 20.0%, respectively. There was no significant difference in clinical characteristics and survival among patients with NSIP preceding CVD diagnosis, those with idiopathic NSIP, or those with CVD-NSIP. In addition, at the time of initial diagnosis, there was no significant difference for the fulfillment of previous criteria such as interstitial pneumonia with autoimmune feature (IPAF) between patients with NSIP preceding CVD diagnosis and those with idiopathic NSIP. Conclusions It is difficult to predict CVD occurrence and careful attention is needed to detect the development of CVD in patients with idiopathic NSIP.

KW - Collagen vascular disease (CVD)

KW - Connective tissue disease (CTD)

KW - Idiopathic interstitial pneumonias (IIPs)

KW - Interstitial pneumonia with autoimmune features (IPAF)

KW - Nonspecific interstitial pneumonia (NSIP)

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