Nonspecific interstitial pneumonia in collagen vascular diseases: Comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia

Yutaro Nakamura, Kingo Chida, Takafumi Suda, Hiroshi Hayakawa, Masatoshi Iwata, Shiro Imokawa, Tomoyoshi Tsuchiya, Masaaki Ida, Hitoshi Gemma, Kazumasa Yasuda, Takeshi Yagi, Toshihiro Shirai, Ryoji Tamura, Yutaka Nakano, Takeo Hirata, Hirotoshi Nakamura, Thomas V. Colby

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background: Nonspecific interstitial pneumonia (NSIP) has recently been described as a distinct clinicopathological entity among idiopathic interstitial pneumonias (IIP), having more favorable prognosis than usual interstitial pneumonia (UIP). Although NSIP was initially reported to also occur in patients with interstitial pneumonia associated with collagen vascular diseases (IP-CVD), the prevalence of NSIP and its prognostic significance in IP-CVD remains to be determined. Thus, we attempted to clarify clinical characteristics and prognostic significance of NSIP in IP-CVD. Methods: We histologically examined surgical lung biopsies from 43 patients with IP-CVD based on a current classification of interstitial pneumonias, and compared the clinical characteristics and prognostic significance of NSIP with UIP in IP-CVD. We also studied 98 patients with biopsy-proven NSIP and UIP in IIP, and compared the prognostic significance of histopathologic subclassification in IIP with that in IP-CVD. Results: In IP-CVD, twenty-six patients (60%) were classified as NSIP, 17 (40%) as UIP. In contrast, 76 (77%) were categorized into UIP and 22 (23%) into NSIP of the patients with IIP. No significant difference in survival rates was observed between UIP and NSIP in IP-CVD (p = 0.3863), while, in IIP, NSIP has a significant better survival than UIP (p = 0.022). Conclusions: These results suggest that NSIP is more common histologic pattern than UIP in IP-CVD and, unlike in IIP, the prognosis of NSIP patients may not be different from that of UIP patients in IP-CVD.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume20
Issue number3
StatePublished - Oct 2003

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Collagen Diseases
Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases
Vascular Diseases
Idiopathic Interstitial Pneumonias

Keywords

  • Collagen Vascular Diseases
  • Nonspecific Interstitial Pneumonia
  • Usual Interstitial Pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Nonspecific interstitial pneumonia in collagen vascular diseases : Comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia. / Nakamura, Yutaro; Chida, Kingo; Suda, Takafumi; Hayakawa, Hiroshi; Iwata, Masatoshi; Imokawa, Shiro; Tsuchiya, Tomoyoshi; Ida, Masaaki; Gemma, Hitoshi; Yasuda, Kazumasa; Yagi, Takeshi; Shirai, Toshihiro; Tamura, Ryoji; Nakano, Yutaka; Hirata, Takeo; Nakamura, Hirotoshi; Colby, Thomas V.

In: Sarcoidosis Vasculitis and Diffuse Lung Diseases, Vol. 20, No. 3, 10.2003, p. 235-241.

Research output: Contribution to journalArticle

Nakamura, Y, Chida, K, Suda, T, Hayakawa, H, Iwata, M, Imokawa, S, Tsuchiya, T, Ida, M, Gemma, H, Yasuda, K, Yagi, T, Shirai, T, Tamura, R, Nakano, Y, Hirata, T, Nakamura, H & Colby, TV 2003, 'Nonspecific interstitial pneumonia in collagen vascular diseases: Comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia', Sarcoidosis Vasculitis and Diffuse Lung Diseases, vol. 20, no. 3, pp. 235-241.
Nakamura, Yutaro ; Chida, Kingo ; Suda, Takafumi ; Hayakawa, Hiroshi ; Iwata, Masatoshi ; Imokawa, Shiro ; Tsuchiya, Tomoyoshi ; Ida, Masaaki ; Gemma, Hitoshi ; Yasuda, Kazumasa ; Yagi, Takeshi ; Shirai, Toshihiro ; Tamura, Ryoji ; Nakano, Yutaka ; Hirata, Takeo ; Nakamura, Hirotoshi ; Colby, Thomas V. / Nonspecific interstitial pneumonia in collagen vascular diseases : Comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia. In: Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2003 ; Vol. 20, No. 3. pp. 235-241.
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abstract = "Background: Nonspecific interstitial pneumonia (NSIP) has recently been described as a distinct clinicopathological entity among idiopathic interstitial pneumonias (IIP), having more favorable prognosis than usual interstitial pneumonia (UIP). Although NSIP was initially reported to also occur in patients with interstitial pneumonia associated with collagen vascular diseases (IP-CVD), the prevalence of NSIP and its prognostic significance in IP-CVD remains to be determined. Thus, we attempted to clarify clinical characteristics and prognostic significance of NSIP in IP-CVD. Methods: We histologically examined surgical lung biopsies from 43 patients with IP-CVD based on a current classification of interstitial pneumonias, and compared the clinical characteristics and prognostic significance of NSIP with UIP in IP-CVD. We also studied 98 patients with biopsy-proven NSIP and UIP in IIP, and compared the prognostic significance of histopathologic subclassification in IIP with that in IP-CVD. Results: In IP-CVD, twenty-six patients (60{\%}) were classified as NSIP, 17 (40{\%}) as UIP. In contrast, 76 (77{\%}) were categorized into UIP and 22 (23{\%}) into NSIP of the patients with IIP. No significant difference in survival rates was observed between UIP and NSIP in IP-CVD (p = 0.3863), while, in IIP, NSIP has a significant better survival than UIP (p = 0.022). Conclusions: These results suggest that NSIP is more common histologic pattern than UIP in IP-CVD and, unlike in IIP, the prognosis of NSIP patients may not be different from that of UIP patients in IP-CVD.",
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T1 - Nonspecific interstitial pneumonia in collagen vascular diseases

T2 - Comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia

AU - Nakamura, Yutaro

AU - Chida, Kingo

AU - Suda, Takafumi

AU - Hayakawa, Hiroshi

AU - Iwata, Masatoshi

AU - Imokawa, Shiro

AU - Tsuchiya, Tomoyoshi

AU - Ida, Masaaki

AU - Gemma, Hitoshi

AU - Yasuda, Kazumasa

AU - Yagi, Takeshi

AU - Shirai, Toshihiro

AU - Tamura, Ryoji

AU - Nakano, Yutaka

AU - Hirata, Takeo

AU - Nakamura, Hirotoshi

AU - Colby, Thomas V.

PY - 2003/10

Y1 - 2003/10

N2 - Background: Nonspecific interstitial pneumonia (NSIP) has recently been described as a distinct clinicopathological entity among idiopathic interstitial pneumonias (IIP), having more favorable prognosis than usual interstitial pneumonia (UIP). Although NSIP was initially reported to also occur in patients with interstitial pneumonia associated with collagen vascular diseases (IP-CVD), the prevalence of NSIP and its prognostic significance in IP-CVD remains to be determined. Thus, we attempted to clarify clinical characteristics and prognostic significance of NSIP in IP-CVD. Methods: We histologically examined surgical lung biopsies from 43 patients with IP-CVD based on a current classification of interstitial pneumonias, and compared the clinical characteristics and prognostic significance of NSIP with UIP in IP-CVD. We also studied 98 patients with biopsy-proven NSIP and UIP in IIP, and compared the prognostic significance of histopathologic subclassification in IIP with that in IP-CVD. Results: In IP-CVD, twenty-six patients (60%) were classified as NSIP, 17 (40%) as UIP. In contrast, 76 (77%) were categorized into UIP and 22 (23%) into NSIP of the patients with IIP. No significant difference in survival rates was observed between UIP and NSIP in IP-CVD (p = 0.3863), while, in IIP, NSIP has a significant better survival than UIP (p = 0.022). Conclusions: These results suggest that NSIP is more common histologic pattern than UIP in IP-CVD and, unlike in IIP, the prognosis of NSIP patients may not be different from that of UIP patients in IP-CVD.

AB - Background: Nonspecific interstitial pneumonia (NSIP) has recently been described as a distinct clinicopathological entity among idiopathic interstitial pneumonias (IIP), having more favorable prognosis than usual interstitial pneumonia (UIP). Although NSIP was initially reported to also occur in patients with interstitial pneumonia associated with collagen vascular diseases (IP-CVD), the prevalence of NSIP and its prognostic significance in IP-CVD remains to be determined. Thus, we attempted to clarify clinical characteristics and prognostic significance of NSIP in IP-CVD. Methods: We histologically examined surgical lung biopsies from 43 patients with IP-CVD based on a current classification of interstitial pneumonias, and compared the clinical characteristics and prognostic significance of NSIP with UIP in IP-CVD. We also studied 98 patients with biopsy-proven NSIP and UIP in IIP, and compared the prognostic significance of histopathologic subclassification in IIP with that in IP-CVD. Results: In IP-CVD, twenty-six patients (60%) were classified as NSIP, 17 (40%) as UIP. In contrast, 76 (77%) were categorized into UIP and 22 (23%) into NSIP of the patients with IIP. No significant difference in survival rates was observed between UIP and NSIP in IP-CVD (p = 0.3863), while, in IIP, NSIP has a significant better survival than UIP (p = 0.022). Conclusions: These results suggest that NSIP is more common histologic pattern than UIP in IP-CVD and, unlike in IIP, the prognosis of NSIP patients may not be different from that of UIP patients in IP-CVD.

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KW - Nonspecific Interstitial Pneumonia

KW - Usual Interstitial Pneumonia

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