Nonspecific interstitial pneumonia

Correlation between thin-section CT findings and pathologic subgroups in 55 patients

Takeshi Johkoh, Nestor L. Müller, Thomas V. Colby, Kazuya Ichikado, Hiroyuki Taniguchi, Yasuhiro Kondoh, Kiminori Fujimoto, Masaharu Kinoshita, Hiroaki Arakawa, Hidehiro Yamada, Moritaka Suga, Masayuki Ando, Mitsuhiro Koyama, Hironobu Nakamura

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

PURPOSE: To characterize thin-section computed tomographic (CT) findings of pathologic subgroups of nonspecific interstitial pneumonia (NIP) in a sizeable number of patients. MATERIALS AND METHODS: The study included 55 cases of pathologically proven NIP. The 55 cases were categorized histologically into four grades: grade 1, interstitial inflammation without fibrosis (n = 6); grade 2, interstitial inflammation predominating over fibrosis (n = 16); grade 3, fibrosis predominating over inflammation (n = 5); and grade 4, fibrosis only (n = 28). Two independent observers evaluated the presence, extent, and distribution of various CT findings. Thin-section CT findings and histologic grades were compared by using the Spearman rank correlation coefficient. Observer agreement was assessed. RESULTS: Areas with ground-glass attenuation and architectural distortion were present in all 55 patients. Traction bronchiectasis and intralobular reticular opacities were seen in 52 and 48 patients, respectively. The extent of traction bronchiectasis (r = 0.68; P < .001) and intralobular reticular opacities (r = 0.35; P < .05) correlated with the histologic grade. Honeycombing was seen in 12 (43%) of 28 patients with grade 4 NIP and in three (11%) of the remaining 27 patients (X2 test, P < .001). There was good agreement between the observers for the presence (κ = 0.7-1.0) and extent (Spearman rank correlation; r = 0.87-0.98; P < .001) of various abnormalities. CONCLUSION: The extent of traction bronchiectasis and intralobular reticulation at thin-section CT correlates with increased fibrosis in NIP. Honeycombing is seen almost exclusively in patients with fibrotic NIP.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalRadiology
Volume225
Issue number1
StatePublished - Oct 1 2002
Externally publishedYes

Fingerprint

Interstitial Lung Diseases
Fibrosis
Bronchiectasis
Traction
Inflammation
Nonparametric Statistics
Glass

Keywords

  • Computed tomography (CT)
  • Nonspecific interstitial and fibrosis
  • Pneumonia
  • Thin-section

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Johkoh, T., Müller, N. L., Colby, T. V., Ichikado, K., Taniguchi, H., Kondoh, Y., ... Nakamura, H. (2002). Nonspecific interstitial pneumonia: Correlation between thin-section CT findings and pathologic subgroups in 55 patients. Radiology, 225(1), 199-204.

Nonspecific interstitial pneumonia : Correlation between thin-section CT findings and pathologic subgroups in 55 patients. / Johkoh, Takeshi; Müller, Nestor L.; Colby, Thomas V.; Ichikado, Kazuya; Taniguchi, Hiroyuki; Kondoh, Yasuhiro; Fujimoto, Kiminori; Kinoshita, Masaharu; Arakawa, Hiroaki; Yamada, Hidehiro; Suga, Moritaka; Ando, Masayuki; Koyama, Mitsuhiro; Nakamura, Hironobu.

In: Radiology, Vol. 225, No. 1, 01.10.2002, p. 199-204.

Research output: Contribution to journalArticle

Johkoh, T, Müller, NL, Colby, TV, Ichikado, K, Taniguchi, H, Kondoh, Y, Fujimoto, K, Kinoshita, M, Arakawa, H, Yamada, H, Suga, M, Ando, M, Koyama, M & Nakamura, H 2002, 'Nonspecific interstitial pneumonia: Correlation between thin-section CT findings and pathologic subgroups in 55 patients', Radiology, vol. 225, no. 1, pp. 199-204.
Johkoh T, Müller NL, Colby TV, Ichikado K, Taniguchi H, Kondoh Y et al. Nonspecific interstitial pneumonia: Correlation between thin-section CT findings and pathologic subgroups in 55 patients. Radiology. 2002 Oct 1;225(1):199-204.
Johkoh, Takeshi ; Müller, Nestor L. ; Colby, Thomas V. ; Ichikado, Kazuya ; Taniguchi, Hiroyuki ; Kondoh, Yasuhiro ; Fujimoto, Kiminori ; Kinoshita, Masaharu ; Arakawa, Hiroaki ; Yamada, Hidehiro ; Suga, Moritaka ; Ando, Masayuki ; Koyama, Mitsuhiro ; Nakamura, Hironobu. / Nonspecific interstitial pneumonia : Correlation between thin-section CT findings and pathologic subgroups in 55 patients. In: Radiology. 2002 ; Vol. 225, No. 1. pp. 199-204.
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abstract = "PURPOSE: To characterize thin-section computed tomographic (CT) findings of pathologic subgroups of nonspecific interstitial pneumonia (NIP) in a sizeable number of patients. MATERIALS AND METHODS: The study included 55 cases of pathologically proven NIP. The 55 cases were categorized histologically into four grades: grade 1, interstitial inflammation without fibrosis (n = 6); grade 2, interstitial inflammation predominating over fibrosis (n = 16); grade 3, fibrosis predominating over inflammation (n = 5); and grade 4, fibrosis only (n = 28). Two independent observers evaluated the presence, extent, and distribution of various CT findings. Thin-section CT findings and histologic grades were compared by using the Spearman rank correlation coefficient. Observer agreement was assessed. RESULTS: Areas with ground-glass attenuation and architectural distortion were present in all 55 patients. Traction bronchiectasis and intralobular reticular opacities were seen in 52 and 48 patients, respectively. The extent of traction bronchiectasis (r = 0.68; P < .001) and intralobular reticular opacities (r = 0.35; P < .05) correlated with the histologic grade. Honeycombing was seen in 12 (43{\%}) of 28 patients with grade 4 NIP and in three (11{\%}) of the remaining 27 patients (X2 test, P < .001). There was good agreement between the observers for the presence (κ = 0.7-1.0) and extent (Spearman rank correlation; r = 0.87-0.98; P < .001) of various abnormalities. CONCLUSION: The extent of traction bronchiectasis and intralobular reticulation at thin-section CT correlates with increased fibrosis in NIP. Honeycombing is seen almost exclusively in patients with fibrotic NIP.",
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T2 - Correlation between thin-section CT findings and pathologic subgroups in 55 patients

AU - Johkoh, Takeshi

AU - Müller, Nestor L.

AU - Colby, Thomas V.

AU - Ichikado, Kazuya

AU - Taniguchi, Hiroyuki

AU - Kondoh, Yasuhiro

AU - Fujimoto, Kiminori

AU - Kinoshita, Masaharu

AU - Arakawa, Hiroaki

AU - Yamada, Hidehiro

AU - Suga, Moritaka

AU - Ando, Masayuki

AU - Koyama, Mitsuhiro

AU - Nakamura, Hironobu

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N2 - PURPOSE: To characterize thin-section computed tomographic (CT) findings of pathologic subgroups of nonspecific interstitial pneumonia (NIP) in a sizeable number of patients. MATERIALS AND METHODS: The study included 55 cases of pathologically proven NIP. The 55 cases were categorized histologically into four grades: grade 1, interstitial inflammation without fibrosis (n = 6); grade 2, interstitial inflammation predominating over fibrosis (n = 16); grade 3, fibrosis predominating over inflammation (n = 5); and grade 4, fibrosis only (n = 28). Two independent observers evaluated the presence, extent, and distribution of various CT findings. Thin-section CT findings and histologic grades were compared by using the Spearman rank correlation coefficient. Observer agreement was assessed. RESULTS: Areas with ground-glass attenuation and architectural distortion were present in all 55 patients. Traction bronchiectasis and intralobular reticular opacities were seen in 52 and 48 patients, respectively. The extent of traction bronchiectasis (r = 0.68; P < .001) and intralobular reticular opacities (r = 0.35; P < .05) correlated with the histologic grade. Honeycombing was seen in 12 (43%) of 28 patients with grade 4 NIP and in three (11%) of the remaining 27 patients (X2 test, P < .001). There was good agreement between the observers for the presence (κ = 0.7-1.0) and extent (Spearman rank correlation; r = 0.87-0.98; P < .001) of various abnormalities. CONCLUSION: The extent of traction bronchiectasis and intralobular reticulation at thin-section CT correlates with increased fibrosis in NIP. Honeycombing is seen almost exclusively in patients with fibrotic NIP.

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KW - Nonspecific interstitial and fibrosis

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