Nonrhabdomyosarcoma soft tissue sarcomas in children

The Mayo Clinic experience

James E. McGrory, Douglas J. Pritchard, Carola A.S. Arndt, Antonio G. Nascimento, Ellen McPhail, Charles M. Rowland

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Eighty-six children to 18 years of age were treated for nonrhabdomyosarcoma soft tissue sarcomas of the trunk and extremities. Synovial sarcoma (31), fibrosarcoma (13), malignant fibrous histiocytoma (11), epithelioid sarcoma (10), and clear cell sarcoma (7) were the most common diagnoses. Four patients presented with metastatic disease. A high percentage of patients presented after biopsy by the referring physician, although this could not be shown to affect outcome. Patients were treated with wide removal of the tumor when possible, with judicious use of adjuvant radiation, or with chemotherapy in selected cases. Mean followup was 11 years. Five- and 10-year survival was 92% and 84%, respectively. Tumors larger than 5 cm were associated with a worse prognosis. When compared with published data in adults, the prognosis of primary, localized nonrhabdomyosarcoma soft tissue sarcomas in children appears to be more favorable.

Original languageEnglish (US)
Pages (from-to)247-258
Number of pages12
JournalClinical Orthopaedics and Related Research
Issue number374
StatePublished - May 2000

Fingerprint

Sarcoma
Clear Cell Sarcoma
Synovial Sarcoma
Malignant Fibrous Histiocytoma
Fibrosarcoma
Neoplasms
Extremities
Radiation
Physicians
Biopsy
Drug Therapy
Survival

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Nonrhabdomyosarcoma soft tissue sarcomas in children : The Mayo Clinic experience. / McGrory, James E.; Pritchard, Douglas J.; Arndt, Carola A.S.; Nascimento, Antonio G.; McPhail, Ellen; Rowland, Charles M.

In: Clinical Orthopaedics and Related Research, No. 374, 05.2000, p. 247-258.

Research output: Contribution to journalArticle

McGrory, James E. ; Pritchard, Douglas J. ; Arndt, Carola A.S. ; Nascimento, Antonio G. ; McPhail, Ellen ; Rowland, Charles M. / Nonrhabdomyosarcoma soft tissue sarcomas in children : The Mayo Clinic experience. In: Clinical Orthopaedics and Related Research. 2000 ; No. 374. pp. 247-258.
@article{578a887dda1b45b5b63bd1e6ef2bd805,
title = "Nonrhabdomyosarcoma soft tissue sarcomas in children: The Mayo Clinic experience",
abstract = "Eighty-six children to 18 years of age were treated for nonrhabdomyosarcoma soft tissue sarcomas of the trunk and extremities. Synovial sarcoma (31), fibrosarcoma (13), malignant fibrous histiocytoma (11), epithelioid sarcoma (10), and clear cell sarcoma (7) were the most common diagnoses. Four patients presented with metastatic disease. A high percentage of patients presented after biopsy by the referring physician, although this could not be shown to affect outcome. Patients were treated with wide removal of the tumor when possible, with judicious use of adjuvant radiation, or with chemotherapy in selected cases. Mean followup was 11 years. Five- and 10-year survival was 92{\%} and 84{\%}, respectively. Tumors larger than 5 cm were associated with a worse prognosis. When compared with published data in adults, the prognosis of primary, localized nonrhabdomyosarcoma soft tissue sarcomas in children appears to be more favorable.",
author = "McGrory, {James E.} and Pritchard, {Douglas J.} and Arndt, {Carola A.S.} and Nascimento, {Antonio G.} and Ellen McPhail and Rowland, {Charles M.}",
year = "2000",
month = "5",
language = "English (US)",
pages = "247--258",
journal = "Clinical Orthopaedics and Related Research",
issn = "0009-921X",
publisher = "Springer New York",
number = "374",

}

TY - JOUR

T1 - Nonrhabdomyosarcoma soft tissue sarcomas in children

T2 - The Mayo Clinic experience

AU - McGrory, James E.

AU - Pritchard, Douglas J.

AU - Arndt, Carola A.S.

AU - Nascimento, Antonio G.

AU - McPhail, Ellen

AU - Rowland, Charles M.

PY - 2000/5

Y1 - 2000/5

N2 - Eighty-six children to 18 years of age were treated for nonrhabdomyosarcoma soft tissue sarcomas of the trunk and extremities. Synovial sarcoma (31), fibrosarcoma (13), malignant fibrous histiocytoma (11), epithelioid sarcoma (10), and clear cell sarcoma (7) were the most common diagnoses. Four patients presented with metastatic disease. A high percentage of patients presented after biopsy by the referring physician, although this could not be shown to affect outcome. Patients were treated with wide removal of the tumor when possible, with judicious use of adjuvant radiation, or with chemotherapy in selected cases. Mean followup was 11 years. Five- and 10-year survival was 92% and 84%, respectively. Tumors larger than 5 cm were associated with a worse prognosis. When compared with published data in adults, the prognosis of primary, localized nonrhabdomyosarcoma soft tissue sarcomas in children appears to be more favorable.

AB - Eighty-six children to 18 years of age were treated for nonrhabdomyosarcoma soft tissue sarcomas of the trunk and extremities. Synovial sarcoma (31), fibrosarcoma (13), malignant fibrous histiocytoma (11), epithelioid sarcoma (10), and clear cell sarcoma (7) were the most common diagnoses. Four patients presented with metastatic disease. A high percentage of patients presented after biopsy by the referring physician, although this could not be shown to affect outcome. Patients were treated with wide removal of the tumor when possible, with judicious use of adjuvant radiation, or with chemotherapy in selected cases. Mean followup was 11 years. Five- and 10-year survival was 92% and 84%, respectively. Tumors larger than 5 cm were associated with a worse prognosis. When compared with published data in adults, the prognosis of primary, localized nonrhabdomyosarcoma soft tissue sarcomas in children appears to be more favorable.

UR - http://www.scopus.com/inward/record.url?scp=0034020932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034020932&partnerID=8YFLogxK

M3 - Article

SP - 247

EP - 258

JO - Clinical Orthopaedics and Related Research

JF - Clinical Orthopaedics and Related Research

SN - 0009-921X

IS - 374

ER -