### Abstract

Pulse wave velocity (PWV) is widely used for estimating the stiffness of an artery. It is well-known that a stiffened artery can be associated with various diseases and with aging. Usually, PWV is measured using the "foot-to-foot" method in which the travel time of the wave is measured over a distance. The "foot" of the pressure wave is not clear due to reflected waves and blood noise. Also, PWV is an average indicator of artery stiffness between the two measuring points and, therefore, does not identify local stiffness variations. We propose producing a bending wave in the arterial wall using low-frequency, localized ultrasound radiation force and measuring the wave velocity along the arterial wall. The wave velocity can be measured accurately over a few millimeters. A mathematical model for wave propagation along the artery is developed with which the Young's modulus of the artery can be determined from measured wave velocities. Experiments were conducted on a pig carotid artery cast in a tissue-mimicking gelatin. The wave velocity was measured by the phase change at a known distance for a given frequency. The measured wave velocity is about 3 m/s at 100 Hz and 6.5 m/s at 500 Hz. The real part of complex elastic modulus of the artery is estimated to be 300 kPa.

Original language | English (US) |
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Pages (from-to) | 642-651 |

Number of pages | 10 |

Journal | IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control |

Volume | 52 |

Issue number | 4 |

DOIs | |

State | Published - Apr 2005 |

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### ASJC Scopus subject areas

- Electrical and Electronic Engineering
- Acoustics and Ultrasonics

### Cite this

**Noninvasive method for estimation of complex elastic modulus of arterial vessels.** / Zhang, Xiaoming; Kinnick, Randall R.; Fatemi, Mostafa; Greenleaf, James F.

Research output: Contribution to journal › Article

}

TY - JOUR

T1 - Noninvasive method for estimation of complex elastic modulus of arterial vessels

AU - Zhang, Xiaoming

AU - Kinnick, Randall R.

AU - Fatemi, Mostafa

AU - Greenleaf, James F

PY - 2005/4

Y1 - 2005/4

N2 - Pulse wave velocity (PWV) is widely used for estimating the stiffness of an artery. It is well-known that a stiffened artery can be associated with various diseases and with aging. Usually, PWV is measured using the "foot-to-foot" method in which the travel time of the wave is measured over a distance. The "foot" of the pressure wave is not clear due to reflected waves and blood noise. Also, PWV is an average indicator of artery stiffness between the two measuring points and, therefore, does not identify local stiffness variations. We propose producing a bending wave in the arterial wall using low-frequency, localized ultrasound radiation force and measuring the wave velocity along the arterial wall. The wave velocity can be measured accurately over a few millimeters. A mathematical model for wave propagation along the artery is developed with which the Young's modulus of the artery can be determined from measured wave velocities. Experiments were conducted on a pig carotid artery cast in a tissue-mimicking gelatin. The wave velocity was measured by the phase change at a known distance for a given frequency. The measured wave velocity is about 3 m/s at 100 Hz and 6.5 m/s at 500 Hz. The real part of complex elastic modulus of the artery is estimated to be 300 kPa.

AB - Pulse wave velocity (PWV) is widely used for estimating the stiffness of an artery. It is well-known that a stiffened artery can be associated with various diseases and with aging. Usually, PWV is measured using the "foot-to-foot" method in which the travel time of the wave is measured over a distance. The "foot" of the pressure wave is not clear due to reflected waves and blood noise. Also, PWV is an average indicator of artery stiffness between the two measuring points and, therefore, does not identify local stiffness variations. We propose producing a bending wave in the arterial wall using low-frequency, localized ultrasound radiation force and measuring the wave velocity along the arterial wall. The wave velocity can be measured accurately over a few millimeters. A mathematical model for wave propagation along the artery is developed with which the Young's modulus of the artery can be determined from measured wave velocities. Experiments were conducted on a pig carotid artery cast in a tissue-mimicking gelatin. The wave velocity was measured by the phase change at a known distance for a given frequency. The measured wave velocity is about 3 m/s at 100 Hz and 6.5 m/s at 500 Hz. The real part of complex elastic modulus of the artery is estimated to be 300 kPa.

UR - http://www.scopus.com/inward/record.url?scp=19344372355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19344372355&partnerID=8YFLogxK

U2 - 10.1109/TUFFC.2005.1428047

DO - 10.1109/TUFFC.2005.1428047

M3 - Article

C2 - 16060513

AN - SCOPUS:19344372355

VL - 52

SP - 642

EP - 651

JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

SN - 0885-3010

IS - 4

ER -