Noninvasive measurements of infarct size after thrombolysis with a necrosis-avid MRI contrast agent

Sorin V. Pislaru, Yicheng Ni, Cristina Pislaru, Hilde Bosmans, Yi Miao, Jan Bogaert, Steven Dymarkowski, Wolfhard Semmler, Guy Marchal, Frans J. Van De Werf

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Background-Gadophrin-2 is a new MRI contrast agent with high affinity for necrotic myocardium. The aim of the study was to evaluate whether noninvasive measurements of infarct size after thrombolysis are possible with gadophrin-2-enhanced MRI. Methods and Results-Coronary artery thrombosis was induced in 3 groups of dogs by the copper-coil technique. Thrombolytic therapy together with aspirin and heparin was initiated after 90 minutes of occlusion. One day (group A), 2 days (group B), or 6 days (group C) after infarction, gadophrin-2 was injected intravenously (50 μmol · kg-1). In vivo T1-weighted segmented turbo-FLASH, in vivo T2-weighted segmented half- Fourier turbo spin echo (HASTE), and T1 and T2-weighted spin-echo MRI of the excised heart were performed 24 hours after gadophrin-2 injection. Regions of strong enhancement were observed on T1-weighted images. Planimetry of short- axis MR images and of corresponding triphenyltetrazolium chloride (TTC)- stained left ventricular (LV) slices showed a close correlation between the enhanced areas and TTC-negative areas for both in vivo (r2=0.98, P < 0.0001; mean difference, 0.9 ± 2.0% [SD] of the LV volume [LVV]) and postmortem (r2 = 0.99, P < 0.0001; mean difference, 0.9 ± 1.4% of LVV) measurements. T2- weighted images overestimated the infarct size by 8.1 ± 5.4% of LVV. The mean infarct size was 10.8 ± 11.6% of LVV (group A), 22.4 ± 11.7% (group B), and 5.1 ± 9.3% (group C). Conclusions-In this animal model, in vivo gadophrin-2-enhanced MRI could precisely determine infarct size after thrombolytic therapy. This technique may be very useful for the noninvasive evaluation of infarct size after reperfusion for AMI.

Original languageEnglish (US)
Pages (from-to)690-696
Number of pages7
JournalCirculation
Volume99
Issue number5
DOIs
StatePublished - Feb 9 1999

    Fingerprint

Keywords

  • Diagnosis
  • Magnetic resonance imaging
  • Myocardial infarction
  • Thrombolysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Pislaru, S. V., Ni, Y., Pislaru, C., Bosmans, H., Miao, Y., Bogaert, J., Dymarkowski, S., Semmler, W., Marchal, G., & Van De Werf, F. J. (1999). Noninvasive measurements of infarct size after thrombolysis with a necrosis-avid MRI contrast agent. Circulation, 99(5), 690-696. https://doi.org/10.1161/01.CIR.99.5.690