Noninvasive measurement of human ascending colon volume

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The capacitance and motor functions of the colon are important determinants of its overall function. A simple, noninvasive method to quantify regional colonic volume is required for further physiologic and pharmacologic studies. Our aim was to determine whether measurements of human ascending colon (AC) volume using two-dimensional (2-D) images are as accurate as estimates using three-dimensional (3-D) images. Five healthy male volunteers each ingested a methacrylate-coated capsule containing 99Tc(m)-labelled Amberlite pellets. Two- and 3-D images were obtained using a gammacamera with single photon emission computed tomography (SPECT) capability. Ascending colon volume was estimated by a variable region of interest (VROI) program and by full-width half-maximum (FWHM) analysis, and results were compared to the volume estimates by SPECT. Full-width half-maximum analysis yielded volume estimates that were not significantly different from SPECT (slope = 1.093; t = 0.51; P > 0.5), whereas VROI estimates were significantly different from volume measurements by SPECT and, hence, considered less accurate (slope = 0.438; t = 4.93; P < 0.02). Thus, the less expensive and more easily available planar imaging technique with analysis by FWHM estimates AC volume as accurately as SPECT.

Original languageEnglish (US)
Pages (from-to)485-489
Number of pages5
JournalNuclear Medicine Communications
Volume14
Issue number6
StatePublished - 1993

Fingerprint

Ascending Colon
Single-Photon Emission-Computed Tomography
Three-Dimensional Imaging
Methacrylates
Capsules
Healthy Volunteers
Colon

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Noninvasive measurement of human ascending colon volume. / Badley, Andrew David; Camilleri, Michael; O'Connor, M. K.

In: Nuclear Medicine Communications, Vol. 14, No. 6, 1993, p. 485-489.

Research output: Contribution to journalArticle

@article{eab63dcf685f44b6b4cc0c24b5cc6b18,
title = "Noninvasive measurement of human ascending colon volume",
abstract = "The capacitance and motor functions of the colon are important determinants of its overall function. A simple, noninvasive method to quantify regional colonic volume is required for further physiologic and pharmacologic studies. Our aim was to determine whether measurements of human ascending colon (AC) volume using two-dimensional (2-D) images are as accurate as estimates using three-dimensional (3-D) images. Five healthy male volunteers each ingested a methacrylate-coated capsule containing 99Tc(m)-labelled Amberlite pellets. Two- and 3-D images were obtained using a gammacamera with single photon emission computed tomography (SPECT) capability. Ascending colon volume was estimated by a variable region of interest (VROI) program and by full-width half-maximum (FWHM) analysis, and results were compared to the volume estimates by SPECT. Full-width half-maximum analysis yielded volume estimates that were not significantly different from SPECT (slope = 1.093; t = 0.51; P > 0.5), whereas VROI estimates were significantly different from volume measurements by SPECT and, hence, considered less accurate (slope = 0.438; t = 4.93; P < 0.02). Thus, the less expensive and more easily available planar imaging technique with analysis by FWHM estimates AC volume as accurately as SPECT.",
author = "Badley, {Andrew David} and Michael Camilleri and O'Connor, {M. K.}",
year = "1993",
language = "English (US)",
volume = "14",
pages = "485--489",
journal = "Nuclear Medicine Communications",
issn = "0143-3636",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Noninvasive measurement of human ascending colon volume

AU - Badley, Andrew David

AU - Camilleri, Michael

AU - O'Connor, M. K.

PY - 1993

Y1 - 1993

N2 - The capacitance and motor functions of the colon are important determinants of its overall function. A simple, noninvasive method to quantify regional colonic volume is required for further physiologic and pharmacologic studies. Our aim was to determine whether measurements of human ascending colon (AC) volume using two-dimensional (2-D) images are as accurate as estimates using three-dimensional (3-D) images. Five healthy male volunteers each ingested a methacrylate-coated capsule containing 99Tc(m)-labelled Amberlite pellets. Two- and 3-D images were obtained using a gammacamera with single photon emission computed tomography (SPECT) capability. Ascending colon volume was estimated by a variable region of interest (VROI) program and by full-width half-maximum (FWHM) analysis, and results were compared to the volume estimates by SPECT. Full-width half-maximum analysis yielded volume estimates that were not significantly different from SPECT (slope = 1.093; t = 0.51; P > 0.5), whereas VROI estimates were significantly different from volume measurements by SPECT and, hence, considered less accurate (slope = 0.438; t = 4.93; P < 0.02). Thus, the less expensive and more easily available planar imaging technique with analysis by FWHM estimates AC volume as accurately as SPECT.

AB - The capacitance and motor functions of the colon are important determinants of its overall function. A simple, noninvasive method to quantify regional colonic volume is required for further physiologic and pharmacologic studies. Our aim was to determine whether measurements of human ascending colon (AC) volume using two-dimensional (2-D) images are as accurate as estimates using three-dimensional (3-D) images. Five healthy male volunteers each ingested a methacrylate-coated capsule containing 99Tc(m)-labelled Amberlite pellets. Two- and 3-D images were obtained using a gammacamera with single photon emission computed tomography (SPECT) capability. Ascending colon volume was estimated by a variable region of interest (VROI) program and by full-width half-maximum (FWHM) analysis, and results were compared to the volume estimates by SPECT. Full-width half-maximum analysis yielded volume estimates that were not significantly different from SPECT (slope = 1.093; t = 0.51; P > 0.5), whereas VROI estimates were significantly different from volume measurements by SPECT and, hence, considered less accurate (slope = 0.438; t = 4.93; P < 0.02). Thus, the less expensive and more easily available planar imaging technique with analysis by FWHM estimates AC volume as accurately as SPECT.

UR - http://www.scopus.com/inward/record.url?scp=0027195932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027195932&partnerID=8YFLogxK

M3 - Article

C2 - 8321488

AN - SCOPUS:0027195932

VL - 14

SP - 485

EP - 489

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 6

ER -