Abstract
Objectives: We evaluated the potential vasodilator effects of transcutaneous low-frequency ultrasound (US) in human brachial arteries. Background: Recent data show that transthoracic low-frequency US energy results in canine coronary artery vasodilation. Methods: Brachial artery diameters were measured before and after low-frequency US (29 kHz, 1.4 W/cm2) exposure using US imaging with a linear-array transducer. We assessed the time course of diameter changes after US in 20 subjects. In 10 of 20 subjects, brachial artery flow-mediated vasodilation (FMD) was measured to compare the effect of US to a standard method of evaluating endothelial function. Results: Significant vasodilation was seen after 2 min of US compared with baseline values. At 5 min of US, the brachial artery diameter increased by 4.1%. In addition, the arteries continued to dilate after US exposure. At 3 min after US there was a 5.4%, and at 5 min after US a 6.0% increase in vessel diameter (p < 0.001). These diameters returned to baseline dimensions about 20 min after stopping US. Ultrasound-mediated vasodilation and percentage FMD showed good correlation (r = 0.87; p < 0.001). Conclusions: This is the first study to demonstrate that noninvasive transcutaneous low-frequency US energy dilates human brachial arteries. This arterial vasodilator effect has a rapid onset (within 2 min), lasts about 20 min, and is similar in magnitude to that of FMD. The vasodilator effect of US may have diagnostic and therapeutic potential in patients with or at risk for vascular disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 532-537 |
| Number of pages | 6 |
| Journal | Journal of the American College of Cardiology |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 1 2006 |
| Externally published | Yes |
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Cite this
Noninvasive Low-Frequency Ultrasound Energy Causes Vasodilation in Humans. / Iida, Kiyoshi; Luo, Huai; Hagisawa, Kohsuke; Akima, Takashi; Shah, Prediman K.; Naqvi, Tasneem Zehra; Siegel, Robert J.
In: Journal of the American College of Cardiology, Vol. 48, No. 3, 01.08.2006, p. 532-537.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noninvasive Low-Frequency Ultrasound Energy Causes Vasodilation in Humans
AU - Iida, Kiyoshi
AU - Luo, Huai
AU - Hagisawa, Kohsuke
AU - Akima, Takashi
AU - Shah, Prediman K.
AU - Naqvi, Tasneem Zehra
AU - Siegel, Robert J.
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Objectives: We evaluated the potential vasodilator effects of transcutaneous low-frequency ultrasound (US) in human brachial arteries. Background: Recent data show that transthoracic low-frequency US energy results in canine coronary artery vasodilation. Methods: Brachial artery diameters were measured before and after low-frequency US (29 kHz, 1.4 W/cm2) exposure using US imaging with a linear-array transducer. We assessed the time course of diameter changes after US in 20 subjects. In 10 of 20 subjects, brachial artery flow-mediated vasodilation (FMD) was measured to compare the effect of US to a standard method of evaluating endothelial function. Results: Significant vasodilation was seen after 2 min of US compared with baseline values. At 5 min of US, the brachial artery diameter increased by 4.1%. In addition, the arteries continued to dilate after US exposure. At 3 min after US there was a 5.4%, and at 5 min after US a 6.0% increase in vessel diameter (p < 0.001). These diameters returned to baseline dimensions about 20 min after stopping US. Ultrasound-mediated vasodilation and percentage FMD showed good correlation (r = 0.87; p < 0.001). Conclusions: This is the first study to demonstrate that noninvasive transcutaneous low-frequency US energy dilates human brachial arteries. This arterial vasodilator effect has a rapid onset (within 2 min), lasts about 20 min, and is similar in magnitude to that of FMD. The vasodilator effect of US may have diagnostic and therapeutic potential in patients with or at risk for vascular disease.
AB - Objectives: We evaluated the potential vasodilator effects of transcutaneous low-frequency ultrasound (US) in human brachial arteries. Background: Recent data show that transthoracic low-frequency US energy results in canine coronary artery vasodilation. Methods: Brachial artery diameters were measured before and after low-frequency US (29 kHz, 1.4 W/cm2) exposure using US imaging with a linear-array transducer. We assessed the time course of diameter changes after US in 20 subjects. In 10 of 20 subjects, brachial artery flow-mediated vasodilation (FMD) was measured to compare the effect of US to a standard method of evaluating endothelial function. Results: Significant vasodilation was seen after 2 min of US compared with baseline values. At 5 min of US, the brachial artery diameter increased by 4.1%. In addition, the arteries continued to dilate after US exposure. At 3 min after US there was a 5.4%, and at 5 min after US a 6.0% increase in vessel diameter (p < 0.001). These diameters returned to baseline dimensions about 20 min after stopping US. Ultrasound-mediated vasodilation and percentage FMD showed good correlation (r = 0.87; p < 0.001). Conclusions: This is the first study to demonstrate that noninvasive transcutaneous low-frequency US energy dilates human brachial arteries. This arterial vasodilator effect has a rapid onset (within 2 min), lasts about 20 min, and is similar in magnitude to that of FMD. The vasodilator effect of US may have diagnostic and therapeutic potential in patients with or at risk for vascular disease.
UR - http://www.scopus.com/inward/record.url?scp=33746257202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746257202&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2006.03.046
DO - 10.1016/j.jacc.2006.03.046
M3 - Article
C2 - 16875980
AN - SCOPUS:33746257202
VL - 48
SP - 532
EP - 537
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 3
ER -