Noninvasive identification of severe coronary artery disease using exercise radionuclide angiography

Raymond J. Gibbons, F. Earl Fyke, Ian P. Clements, Andre C. Lapeyre, Alan R. Zinsmeister, Manuel L. Brown

Research output: Contribution to journalArticle

60 Scopus citations


The ability of exercise radionuclide angiography to predict the risk of having significant left main or three vessel coronary artery disease was examined in 681 patients who underwent both radionuclide and coronary angiography. There were significant differences in multiple variables between patients with or without such disease. Logistic regression analysis identified seven variables as independently predictive of the presence of left main or three vessel disease. Using these variables, low, intermediate and high probability groups could be identified. The four most important variables-the magnitude of exercise ST segment depression, peak exercise ejection fraction, peak exercise rate-pressure product and sex of the patient-can provide practical estimates of the risk of having ten main or three vessel disease. Exercise radionuclide angiography can provide a clinically useful uoninvasive estimate of the risk of having significant left main or three vessel disease.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalJournal of the American College of Cardiology
Issue number1
StatePublished - Jan 1988


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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