Noninvasive assessment of cardiac outut by brachial occlusion-cuff technique: Comparison with the open-circuit acetylene washin method

Pavol Sajgalik, Vaclav Kremen, Alex R. Carlson, Vratislav Fabian, Chul Ho Kim, Courtney Wheatley, Vaclav Gerla, John A. Schirger, Thomas P. Olson, Bruce D. Johnson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Cardiac output (CO) assessment as a basic hemodynamic parameter has been of interest in exercise physiology, cardiology, and anesthesiology. Noninvasive techniques available are technically challenging, and thus difficult to use outside of a clinical or laboratory setting. We propose a novel method of noninvasive CO assessment using a single, upper-arm cuff. The method uses the arterial pressure pulse wave signal acquired from the brachial artery during 20-s intervals of suprasystolic occlusion. This method was evaluated in a cohort of 12 healthy individuals (age, 27.7 ± 5.4 yr, 50% men) and compared with an established method for noninvasive CO assessment, the open-circuit acetylene method (OpCirc) at rest, and during low- to moderate-intensity exercise. CO increased from rest to exercise (rest, 7.4 ± 0.8 vs. 7.2 ± 0.8; low, 9.8 ± 1.8 vs. 9.9 ± 2.0; moderate, 14.1 ± 2.8 vs. 14.8 ± 3.2 l/min) as assessed by the cuff-occlusion and OpCirc techniques, respectively. The average error of experimental technique compared with OpCirc was -0.25 ± 1.02 l/min, Pearson's correlation coefficient of 0.96 (rest + exercise), and 0.21 ± 0.42 l/min with Pearson's correlation coefficient of 0.87 (rest only). Bland-Altman analysis demonstrated good agreement between methods (within 95% boundaries); the reproducibility coefficient (RPC) = 0.84 l/min with R2 = 0.75 at rest and RPC = 2 l/min with R2 = 0.92 at rest and during exercise, respectively. In comparison with an established method to quantify CO, the cuff-occlusion method provides similar measures at rest and with light to moderate exercise. Thus, we believe this method has the potential to be used as a new, noninvasive method for assessing CO during exercise.

Original languageEnglish (US)
Pages (from-to)1319-1325
Number of pages7
JournalJournal of applied physiology
Issue number6
StatePublished - Dec 2016


  • Brachial cuff
  • Cardiac output
  • Noninvasive
  • Occlusion

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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