Nonidentical expressions of multiple endocrine neoplasia, type I, in identical twins

R. S. Bahn, B. W. Scheithauer, J. A. van Heerden, E. R. Laws, E. Horvath, H. Gharib

Research output: Contribution to journalArticle

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Abstract

We studied 25-year-old HLA- and blood group-identical male twins who had multiple endocrine neoplasia, type I (MEN I). At the time of initial examination, one twin (case 1) had epigastric pain and diarrhea; he was cushingoid in appearance. Further evaluation revealed primary hyperparathyroidism Zollinger-Ellison syndrome, Cushing's disease, and hyperprolactinemia. Immunostaining of a resected pituitary specimen demonstrated both prolactin and, to a lesser extent, growth hormone reactivity. The nontumorous adenohypophysis showed corticotropic hyperplasia. In contrast, the other twin (case 2) was asymptomatic. He had only primary hyperparathyroidism and hyperprolactinemia. An invasive pituitary adenoma was resected and showed similar proportions of cells with immunoreactive prolactin and those with growth hormone; no nontumorous gland was available for study. Apparently, factors other than heredity may play a role in the expression of MEN I.

Original languageEnglish (US)
Pages (from-to)689-696
Number of pages8
JournalMayo Clinic Proceedings
Volume61
Issue number9
StatePublished - 1986

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Multiple Endocrine Neoplasia Type 1
Hyperprolactinemia
Monozygotic Twins
Primary Hyperparathyroidism
Prolactin
Growth Hormone
Zollinger-Ellison Syndrome
Pituitary ACTH Hypersecretion
Heredity
Anterior Pituitary Gland
Pituitary Neoplasms
Blood Group Antigens
Hyperplasia
Diarrhea
Pain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bahn, R. S., Scheithauer, B. W., van Heerden, J. A., Laws, E. R., Horvath, E., & Gharib, H. (1986). Nonidentical expressions of multiple endocrine neoplasia, type I, in identical twins. Mayo Clinic Proceedings, 61(9), 689-696.

Nonidentical expressions of multiple endocrine neoplasia, type I, in identical twins. / Bahn, R. S.; Scheithauer, B. W.; van Heerden, J. A.; Laws, E. R.; Horvath, E.; Gharib, H.

In: Mayo Clinic Proceedings, Vol. 61, No. 9, 1986, p. 689-696.

Research output: Contribution to journalArticle

Bahn, RS, Scheithauer, BW, van Heerden, JA, Laws, ER, Horvath, E & Gharib, H 1986, 'Nonidentical expressions of multiple endocrine neoplasia, type I, in identical twins', Mayo Clinic Proceedings, vol. 61, no. 9, pp. 689-696.
Bahn RS, Scheithauer BW, van Heerden JA, Laws ER, Horvath E, Gharib H. Nonidentical expressions of multiple endocrine neoplasia, type I, in identical twins. Mayo Clinic Proceedings. 1986;61(9):689-696.
Bahn, R. S. ; Scheithauer, B. W. ; van Heerden, J. A. ; Laws, E. R. ; Horvath, E. ; Gharib, H. / Nonidentical expressions of multiple endocrine neoplasia, type I, in identical twins. In: Mayo Clinic Proceedings. 1986 ; Vol. 61, No. 9. pp. 689-696.
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