Nonhuman leukocyte antigen antibodies that have impact in the heart transplant patient

Yogesh N.V. Reddy, Naveen L. Pereira

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Purpose of reviewDespite human leukocyte antigen (HLA) matching and monitoring for donor-specific HLA antibodies, antibody-mediated rejection and chronic rejection in the form of allograft vasculopathy and chronic graft dysfunction continue to occur. There has been increasing interest in non-HLA antibodies as mediators of these changes.Recent findingsIn this review, we discuss the recent literature describing the importance of non-HLA antibodies in organ transplantation and summarize the literature evaluating such antibodies in heart transplantation.SummaryMonitoring of non-HLA antibodies requires additional measurement standardization and correlation of specific antibodies with outcomes. However, there is promise that identification with newer immunoproteomic techniques and therapy toward such antibodies may improve long-term graft outcomes and decrease acute rejection and allograft vasculopathy.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalCurrent opinion in organ transplantation
Volume24
Issue number3
DOIs
StatePublished - Jun 1 2019

Keywords

  • allograft vasculopathy
  • antibody-mediated rejection
  • heart transplantation
  • nonhuman leukocyte antigen antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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