Abstract
Purpose of reviewDespite human leukocyte antigen (HLA) matching and monitoring for donor-specific HLA antibodies, antibody-mediated rejection and chronic rejection in the form of allograft vasculopathy and chronic graft dysfunction continue to occur. There has been increasing interest in non-HLA antibodies as mediators of these changes.Recent findingsIn this review, we discuss the recent literature describing the importance of non-HLA antibodies in organ transplantation and summarize the literature evaluating such antibodies in heart transplantation.SummaryMonitoring of non-HLA antibodies requires additional measurement standardization and correlation of specific antibodies with outcomes. However, there is promise that identification with newer immunoproteomic techniques and therapy toward such antibodies may improve long-term graft outcomes and decrease acute rejection and allograft vasculopathy.
Original language | English (US) |
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Pages (from-to) | 279-285 |
Number of pages | 7 |
Journal | Current opinion in organ transplantation |
Volume | 24 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1 2019 |
Keywords
- allograft vasculopathy
- antibody-mediated rejection
- heart transplantation
- nonhuman leukocyte antigen antibodies
ASJC Scopus subject areas
- Immunology and Allergy
- Transplantation