Nonfatal cancer preceding Parkinson's disease: A case-control study

Alexis Elbaz, Brett J. Peterson, Ping Yang, Jay A Van Gerpen, James Howard Bower, Demetrius M. Maraganore, Shannon K. McDonnell, J. Eric Ahlskog, Walter A Rocca

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Abstract

Background. We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer. Methods. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, MN (1976-1995). Each case was matched by age and sex to a general population control. We ascertained cancer diagnoses through medical records abstraction. Results. The frequency of any cancer was lower in cases (19.4%) than in controls (23.5%) (OR = 0.79; 95% CI = 0.49-1.27). This pattern was more pronounced in women than in men, and in patients age 71 years or younger at onset of PD than in older patients. We found an interaction between smoking and smoking-related cancers in their association with PD. Bladder cancer (OR = 0.22; 95% CI = 0.03-2.24) and breast cancer (OR = 0.20; 95% CI = 0.02-1.71) were less frequent in PD cases than in controls, whereas prostate cancer was more frequent in PD cases than in controls (OR = 1.80; 95% CI = 0.60-5.37). However, these results are based on small numbers. Conclusions. We did not find a strong association between PD and preceding nonfatal cancer. There were suggestive trends in analyses stratified by sex and age at onset of PD, and for specific cancers related to smoking or hormonal factors.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalEpidemiology
Volume13
Issue number2
DOIs
StatePublished - 2002

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Parkinson Disease
Case-Control Studies
Neoplasms
Smoking
Medical Record Linkage
Population Control
Urinary Bladder Neoplasms
Medical Records
Prostatic Neoplasms
Epidemiology
Breast Neoplasms
Population

Keywords

  • Cancer
  • Case-control studies
  • Comorbidity
  • Parkinson's disease

ASJC Scopus subject areas

  • Epidemiology

Cite this

Nonfatal cancer preceding Parkinson's disease : A case-control study. / Elbaz, Alexis; Peterson, Brett J.; Yang, Ping; Van Gerpen, Jay A; Bower, James Howard; Maraganore, Demetrius M.; McDonnell, Shannon K.; Ahlskog, J. Eric; Rocca, Walter A.

In: Epidemiology, Vol. 13, No. 2, 2002, p. 157-164.

Research output: Contribution to journalArticle

Elbaz, A, Peterson, BJ, Yang, P, Van Gerpen, JA, Bower, JH, Maraganore, DM, McDonnell, SK, Ahlskog, JE & Rocca, WA 2002, 'Nonfatal cancer preceding Parkinson's disease: A case-control study', Epidemiology, vol. 13, no. 2, pp. 157-164. https://doi.org/10.1097/00001648-200203000-00010
Elbaz, Alexis ; Peterson, Brett J. ; Yang, Ping ; Van Gerpen, Jay A ; Bower, James Howard ; Maraganore, Demetrius M. ; McDonnell, Shannon K. ; Ahlskog, J. Eric ; Rocca, Walter A. / Nonfatal cancer preceding Parkinson's disease : A case-control study. In: Epidemiology. 2002 ; Vol. 13, No. 2. pp. 157-164.
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abstract = "Background. We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer. Methods. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, MN (1976-1995). Each case was matched by age and sex to a general population control. We ascertained cancer diagnoses through medical records abstraction. Results. The frequency of any cancer was lower in cases (19.4{\%}) than in controls (23.5{\%}) (OR = 0.79; 95{\%} CI = 0.49-1.27). This pattern was more pronounced in women than in men, and in patients age 71 years or younger at onset of PD than in older patients. We found an interaction between smoking and smoking-related cancers in their association with PD. Bladder cancer (OR = 0.22; 95{\%} CI = 0.03-2.24) and breast cancer (OR = 0.20; 95{\%} CI = 0.02-1.71) were less frequent in PD cases than in controls, whereas prostate cancer was more frequent in PD cases than in controls (OR = 1.80; 95{\%} CI = 0.60-5.37). However, these results are based on small numbers. Conclusions. We did not find a strong association between PD and preceding nonfatal cancer. There were suggestive trends in analyses stratified by sex and age at onset of PD, and for specific cancers related to smoking or hormonal factors.",
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AU - Elbaz, Alexis

AU - Peterson, Brett J.

AU - Yang, Ping

AU - Van Gerpen, Jay A

AU - Bower, James Howard

AU - Maraganore, Demetrius M.

AU - McDonnell, Shannon K.

AU - Ahlskog, J. Eric

AU - Rocca, Walter A

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N2 - Background. We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer. Methods. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, MN (1976-1995). Each case was matched by age and sex to a general population control. We ascertained cancer diagnoses through medical records abstraction. Results. The frequency of any cancer was lower in cases (19.4%) than in controls (23.5%) (OR = 0.79; 95% CI = 0.49-1.27). This pattern was more pronounced in women than in men, and in patients age 71 years or younger at onset of PD than in older patients. We found an interaction between smoking and smoking-related cancers in their association with PD. Bladder cancer (OR = 0.22; 95% CI = 0.03-2.24) and breast cancer (OR = 0.20; 95% CI = 0.02-1.71) were less frequent in PD cases than in controls, whereas prostate cancer was more frequent in PD cases than in controls (OR = 1.80; 95% CI = 0.60-5.37). However, these results are based on small numbers. Conclusions. We did not find a strong association between PD and preceding nonfatal cancer. There were suggestive trends in analyses stratified by sex and age at onset of PD, and for specific cancers related to smoking or hormonal factors.

AB - Background. We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer. Methods. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, MN (1976-1995). Each case was matched by age and sex to a general population control. We ascertained cancer diagnoses through medical records abstraction. Results. The frequency of any cancer was lower in cases (19.4%) than in controls (23.5%) (OR = 0.79; 95% CI = 0.49-1.27). This pattern was more pronounced in women than in men, and in patients age 71 years or younger at onset of PD than in older patients. We found an interaction between smoking and smoking-related cancers in their association with PD. Bladder cancer (OR = 0.22; 95% CI = 0.03-2.24) and breast cancer (OR = 0.20; 95% CI = 0.02-1.71) were less frequent in PD cases than in controls, whereas prostate cancer was more frequent in PD cases than in controls (OR = 1.80; 95% CI = 0.60-5.37). However, these results are based on small numbers. Conclusions. We did not find a strong association between PD and preceding nonfatal cancer. There were suggestive trends in analyses stratified by sex and age at onset of PD, and for specific cancers related to smoking or hormonal factors.

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KW - Case-control studies

KW - Comorbidity

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