Nonenzymatic glycosylation of vitreous proteins In vitro and in the streptozocin-treated diabetic rat

Thomas K. Shires, Jon A. Faeth, Jose S. Pulido

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Nonenzymatic glycosylation has been shown to affect collagen elsewhere in the body in diabetic patients. A fluorescent product of nonenzymatic glycosylation of protein was found to accumulate in the vitreous of rats 2 months after diabetogenic doses of streptozotocin. The same product could be demonstrated in the same time frame after in vitro incubation of glucose with insoluble protein constituents isolated from vitreous. These in vitro and in vivo studies show that nonenzymatic glycosylation of vitreous collagens does occur. Further studies to examine whether nonenzymatic glycosylation affects vitreous collagen function should be performed.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalRetina
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1990

Keywords

  • Collagen
  • Diabetes
  • Nonenzymatic glycosylation
  • Streptozotocin
  • Vitreous

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Nonenzymatic glycosylation of vitreous proteins In vitro and in the streptozocin-treated diabetic rat'. Together they form a unique fingerprint.

  • Cite this