Nonconvulsive Status With Metronidazole

A. A. Cantador, James F Meschia, W. D. Freeman, W. O. Tatum

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

To expand the adverse events associated with metronidazole to include nonconvulsive status epilepticus (NCSE). Observational single case report of a rare association. Setting: Hospitalized lung transplant recipient treated with metronidazole for prevention of infection. A 56-year-old man with systemic symptoms, peripheral neuropathy, generalized seizure, and a subsequent acute deterioration of mental status due to NCSE. Administration of midazolam was successful in terminating status epilepticus. Abrupt termination of NCSE was evident on continuous bedside electroencephalogam associated with clinical resolution of mental status. Recovery occurred from NCSE eventually deteriorating to a fatal outcome. Conclusions: Metronidazole may be associated with successfully treated NCSE.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalThe Neurohospitalist
Volume3
Issue number4
DOIs
StatePublished - 2013

Keywords

  • EEG
  • encephalopathy
  • metronidazole
  • nonconvulsive status epilepticus
  • organ transplant

ASJC Scopus subject areas

  • Clinical Neurology

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