Nonbiologic Immune Suppression in Ulcerative Colitis

Valérie Heron; Edward V. Loftus

doi:10.1016/j.gtc.2020.07.003

Nonbiologic Immune Suppression in Ulcerative Colitis

Valérie Heron, Edward V. Loftus

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

Abstract

This article reviews nonbiologic immunosuppressive agents in the induction and maintenance of remission of ulcerative colitis. Based on meta-analyses and North American guidelines, azathioprine, mercaptopurine, and methotrexate monotherapy are not recommended for induction therapy. Thiopurines are recommended in combination with infliximab. Tofacitinib has been shown to be an effective induction agent. Cyclosporine or tacrolimus are calcineurin inhibitors that can be used as induction therapy. Thiopurine monotherapy is suggested or recommended as maintenance therapy for patients who have achieved steroid-induced remission. Methotrexate monotherapy is not recommended. Tofacitinib has been shown to be an effective maintenance agent in moderate to severe disease.

Original language	English (US)
Pages (from-to)	731-738
Number of pages	8
Journal	Gastroenterology Clinics of North America
Volume	49
Issue number	4
DOIs	https://doi.org/10.1016/j.gtc.2020.07.003
State	Published - Dec 2020

Keywords

Azathioprine
Cyclosporine
Mercaptopurine
Methotrexate
Tacrolimus
Tofacitinib
Ulcerative colitis

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.gtc.2020.07.003

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title = "Nonbiologic Immune Suppression in Ulcerative Colitis",

abstract = "This article reviews nonbiologic immunosuppressive agents in the induction and maintenance of remission of ulcerative colitis. Based on meta-analyses and North American guidelines, azathioprine, mercaptopurine, and methotrexate monotherapy are not recommended for induction therapy. Thiopurines are recommended in combination with infliximab. Tofacitinib has been shown to be an effective induction agent. Cyclosporine or tacrolimus are calcineurin inhibitors that can be used as induction therapy. Thiopurine monotherapy is suggested or recommended as maintenance therapy for patients who have achieved steroid-induced remission. Methotrexate monotherapy is not recommended. Tofacitinib has been shown to be an effective maintenance agent in moderate to severe disease.",

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AU - Loftus, Edward V.

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AB - This article reviews nonbiologic immunosuppressive agents in the induction and maintenance of remission of ulcerative colitis. Based on meta-analyses and North American guidelines, azathioprine, mercaptopurine, and methotrexate monotherapy are not recommended for induction therapy. Thiopurines are recommended in combination with infliximab. Tofacitinib has been shown to be an effective induction agent. Cyclosporine or tacrolimus are calcineurin inhibitors that can be used as induction therapy. Thiopurine monotherapy is suggested or recommended as maintenance therapy for patients who have achieved steroid-induced remission. Methotrexate monotherapy is not recommended. Tofacitinib has been shown to be an effective maintenance agent in moderate to severe disease.

KW - Azathioprine

KW - Cyclosporine

KW - Mercaptopurine

KW - Methotrexate

KW - Tacrolimus

KW - Tofacitinib

KW - Ulcerative colitis

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Nonbiologic Immune Suppression in Ulcerative Colitis

Abstract

Keywords

ASJC Scopus subject areas

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