Nonantibiotic effects of fluoroquinolones in mammalian cells

Sujan Badal, Yeng F. Her, L. James Maher

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Background: Fe(II)-dependent dioxygenases regulate epigenetic control, collagen maturation, and HIF degradation. Results: Iron chelation by fluoroquinolone antibiotics results in DNA and histone hypermethylation, suppression of collagen prolyl hydroxylation, and inhibition of HIF mRNA translation. Conclusion: Dioxygenase inhibition may explain renal toxicity and tendinopathy side effects of fluoroquinolones. Significance: This study suggests mechanisms for obscure fluoroquinolone-associated side effects and possible novel applications of these antibiotics as HIF antagonists.

Original languageEnglish (US)
Pages (from-to)22287-22297
Number of pages11
JournalJournal of Biological Chemistry
Volume290
Issue number36
DOIs
StatePublished - Sep 4 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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