Abstract
Background: Fe(II)-dependent dioxygenases regulate epigenetic control, collagen maturation, and HIF degradation. Results: Iron chelation by fluoroquinolone antibiotics results in DNA and histone hypermethylation, suppression of collagen prolyl hydroxylation, and inhibition of HIF mRNA translation. Conclusion: Dioxygenase inhibition may explain renal toxicity and tendinopathy side effects of fluoroquinolones. Significance: This study suggests mechanisms for obscure fluoroquinolone-associated side effects and possible novel applications of these antibiotics as HIF antagonists.
Original language | English (US) |
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Pages (from-to) | 22287-22297 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 36 |
DOIs | |
State | Published - Sep 4 2015 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology