Nonalcoholic fatty liver disease and albuminuria: A systematic review and meta-analysis

Karn Wijarnpreecha, Charat Thongprayoon, Boonphiphop Boonpheng, Panadeekarn Panjawatanan, Konika Sharma, Patompong Ungprasert, Surakit Pungpapong, Wisit Cheungpasitporn

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Background/objectives The relationship between nonalcoholic fatty liver disease (NAFLD) and albuminuria has been shown in many epidemiologic studies, although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of albuminuria among patients with NAFLD. Methods Comprehensive literature review was conducted utilizing Medline and Embase database through January 2018 to identify studies that compared the risk of albuminuria among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results Nineteen studies (17 cross-sectional studies and two cohort studies) with 24 804 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of albuminuria among patients with NAFLD was significantly higher than those without NAFLD with the pooled odds ratio (OR) of 1.67 [95% confidence interval (CI): 1.32-2.11]. Subgroup analysis demonstrated the significantly increased risk of albuminuria among patients with NAFLD without diabetes with pooled OR of 2.25 (95% CI: 1.65-3.06). However, we found no significant association between albuminuria and NAFLD among diabetic patients [pooled OR 1.28 (95% CI: 0.94-1.75)]. Conclusion A significantly increased risk of albuminuria among patients with NAFLD was observed in this meta-analysis. Physicians should pay more attention to the early detection and subsequent treatment of individuals with microalbuminuria especially in patients with NAFLD.

Original languageEnglish (US)
Pages (from-to)986-994
Number of pages9
JournalEuropean Journal of Gastroenterology and Hepatology
Volume30
Issue number9
DOIs
StatePublished - Sep 1 2018

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Albuminuria
Meta-Analysis
Odds Ratio
Confidence Intervals
Non-alcoholic Fatty Liver Disease
Epidemiologic Studies
Cohort Studies
Cross-Sectional Studies
Databases
Physicians

Keywords

  • albuminuria
  • meta-analysis
  • nonalcoholic fatty liver disease
  • nonalcoholic steatohepatitis
  • proteinuria

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Wijarnpreecha, K., Thongprayoon, C., Boonpheng, B., Panjawatanan, P., Sharma, K., Ungprasert, P., ... Cheungpasitporn, W. (2018). Nonalcoholic fatty liver disease and albuminuria: A systematic review and meta-analysis. European Journal of Gastroenterology and Hepatology, 30(9), 986-994. https://doi.org/10.1097/MEG.0000000000001169

Nonalcoholic fatty liver disease and albuminuria : A systematic review and meta-analysis. / Wijarnpreecha, Karn; Thongprayoon, Charat; Boonpheng, Boonphiphop; Panjawatanan, Panadeekarn; Sharma, Konika; Ungprasert, Patompong; Pungpapong, Surakit; Cheungpasitporn, Wisit.

In: European Journal of Gastroenterology and Hepatology, Vol. 30, No. 9, 01.09.2018, p. 986-994.

Research output: Contribution to journalReview article

Wijarnpreecha, K, Thongprayoon, C, Boonpheng, B, Panjawatanan, P, Sharma, K, Ungprasert, P, Pungpapong, S & Cheungpasitporn, W 2018, 'Nonalcoholic fatty liver disease and albuminuria: A systematic review and meta-analysis', European Journal of Gastroenterology and Hepatology, vol. 30, no. 9, pp. 986-994. https://doi.org/10.1097/MEG.0000000000001169
Wijarnpreecha K, Thongprayoon C, Boonpheng B, Panjawatanan P, Sharma K, Ungprasert P et al. Nonalcoholic fatty liver disease and albuminuria: A systematic review and meta-analysis. European Journal of Gastroenterology and Hepatology. 2018 Sep 1;30(9):986-994. https://doi.org/10.1097/MEG.0000000000001169
Wijarnpreecha, Karn ; Thongprayoon, Charat ; Boonpheng, Boonphiphop ; Panjawatanan, Panadeekarn ; Sharma, Konika ; Ungprasert, Patompong ; Pungpapong, Surakit ; Cheungpasitporn, Wisit. / Nonalcoholic fatty liver disease and albuminuria : A systematic review and meta-analysis. In: European Journal of Gastroenterology and Hepatology. 2018 ; Vol. 30, No. 9. pp. 986-994.
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abstract = "Background/objectives The relationship between nonalcoholic fatty liver disease (NAFLD) and albuminuria has been shown in many epidemiologic studies, although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of albuminuria among patients with NAFLD. Methods Comprehensive literature review was conducted utilizing Medline and Embase database through January 2018 to identify studies that compared the risk of albuminuria among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results Nineteen studies (17 cross-sectional studies and two cohort studies) with 24 804 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of albuminuria among patients with NAFLD was significantly higher than those without NAFLD with the pooled odds ratio (OR) of 1.67 [95{\%} confidence interval (CI): 1.32-2.11]. Subgroup analysis demonstrated the significantly increased risk of albuminuria among patients with NAFLD without diabetes with pooled OR of 2.25 (95{\%} CI: 1.65-3.06). However, we found no significant association between albuminuria and NAFLD among diabetic patients [pooled OR 1.28 (95{\%} CI: 0.94-1.75)]. Conclusion A significantly increased risk of albuminuria among patients with NAFLD was observed in this meta-analysis. Physicians should pay more attention to the early detection and subsequent treatment of individuals with microalbuminuria especially in patients with NAFLD.",
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AU - Sharma, Konika

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N2 - Background/objectives The relationship between nonalcoholic fatty liver disease (NAFLD) and albuminuria has been shown in many epidemiologic studies, although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of albuminuria among patients with NAFLD. Methods Comprehensive literature review was conducted utilizing Medline and Embase database through January 2018 to identify studies that compared the risk of albuminuria among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results Nineteen studies (17 cross-sectional studies and two cohort studies) with 24 804 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of albuminuria among patients with NAFLD was significantly higher than those without NAFLD with the pooled odds ratio (OR) of 1.67 [95% confidence interval (CI): 1.32-2.11]. Subgroup analysis demonstrated the significantly increased risk of albuminuria among patients with NAFLD without diabetes with pooled OR of 2.25 (95% CI: 1.65-3.06). However, we found no significant association between albuminuria and NAFLD among diabetic patients [pooled OR 1.28 (95% CI: 0.94-1.75)]. Conclusion A significantly increased risk of albuminuria among patients with NAFLD was observed in this meta-analysis. Physicians should pay more attention to the early detection and subsequent treatment of individuals with microalbuminuria especially in patients with NAFLD.

AB - Background/objectives The relationship between nonalcoholic fatty liver disease (NAFLD) and albuminuria has been shown in many epidemiologic studies, although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of albuminuria among patients with NAFLD. Methods Comprehensive literature review was conducted utilizing Medline and Embase database through January 2018 to identify studies that compared the risk of albuminuria among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results Nineteen studies (17 cross-sectional studies and two cohort studies) with 24 804 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of albuminuria among patients with NAFLD was significantly higher than those without NAFLD with the pooled odds ratio (OR) of 1.67 [95% confidence interval (CI): 1.32-2.11]. Subgroup analysis demonstrated the significantly increased risk of albuminuria among patients with NAFLD without diabetes with pooled OR of 2.25 (95% CI: 1.65-3.06). However, we found no significant association between albuminuria and NAFLD among diabetic patients [pooled OR 1.28 (95% CI: 0.94-1.75)]. Conclusion A significantly increased risk of albuminuria among patients with NAFLD was observed in this meta-analysis. Physicians should pay more attention to the early detection and subsequent treatment of individuals with microalbuminuria especially in patients with NAFLD.

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