Non‐A, Non‐B Fulminant Hepatitis is also Non‐E and Non‐C

Scott K. Kuwada, Vinaychandra M. Patel, F. Blaine Hollinger, H. J. Lin, Patrice O. Yarbough, Russell H. Wiesner, Dorothy Kaese, Jorge Rakela

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Objectives: to define the roles of the hepatitis C and E viruses (HCV and HEV) in non‐A, non‐B (NANB) fulminant hepatitis. Methods: we utilized the polymer‐ase chain reaction to amplify HCV and HEV RNA sequences and assays to detect antibodies to HCV and HEV in the acute phase sera of eight presumed viral NANB and seven nonviral NANB fulminant hepatic failure (FHF) patients. Results: none of the 15 patients had detectable HCV or HEV RNA or elevated HCV and IgM‐HEV antibody titers in their acute phase sera. Three patients, all with features of autoimmune hepatitis, had raised IgG‐HEV antibody titers. Due to the possibility of serologically undetectable hepatitis B virus (HBV) infection in fulminant hepatitis patients, we performed polymerase chain reaction amplification of HBV genomic DNA in acute phase sera of the presumed viral NANB FHF patients and subsequently found no evidence of HBV DNA. Conclusions: we did not find evidence implicating HCV or HEV in presumed viral NANB FHF or as agents contributing to or causing the liver failure in nonviral NANB FHF patients with au‐toimmune hepatitis, drug‐induced hepatotoxicity, or ha‐lothane hepatotoxicity.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalThe American Journal of Gastroenterology
Volume89
Issue number1
DOIs
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Kuwada, S. K., Patel, V. M., Hollinger, F. B., Lin, H. J., Yarbough, P. O., Wiesner, R. H., Kaese, D., & Rakela, J. (1994). Non‐A, Non‐B Fulminant Hepatitis is also Non‐E and Non‐C. The American Journal of Gastroenterology, 89(1), 57-61. https://doi.org/10.1111/j.1572-0241.1994.tb07657.x