Abstract
Non-tuberculous mycobacteria are ubiquitous environmental organisms that are now increasingly recognized as important causes of clinical disease in solid organ transplant recipients. Risk factors of non-tuberculous mycobacteria infection are severe immunologic defects and structural abnormalities. Lung transplant recipients are at higher risk for non-tuberculous mycobacterial disease compared to recipients of other solid organs. The clinical presentation could be skin and soft tissue infection, osteoarticular disease, pleuropulmonary infection, bloodstream (including catheter-associated) infection, lymphadenitis, and disseminated or multi-organ disease. Management of non-tuberculous mycobacteria infection is complex due to the prolonged treatment course with multi-drug regimens that are anticipated to interact with immunosuppressive medications. This review article provides an update on infections due to non-tuberculous mycobacteria after solid organ transplantation, and discusses the epidemiology, risk factors, clinical presentation, and management.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| Volume | 4 |
| DOIs | |
| State | Published - Aug 1 2016 |
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Keywords
- Drug interactions
- Lung transplantation
- Mycobacteria
- Pneumonia
- Transplantation
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Infectious Diseases
- Microbiology (medical)
Cite this
Non-tuberculous mycobacterial infections in solid organ transplant recipients : An update. / Abad, Cybele L.; Razonable, Raymund R.
In: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol. 4, 01.08.2016, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Non-tuberculous mycobacterial infections in solid organ transplant recipients
T2 - An update
AU - Abad, Cybele L.
AU - Razonable, Raymund R
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Non-tuberculous mycobacteria are ubiquitous environmental organisms that are now increasingly recognized as important causes of clinical disease in solid organ transplant recipients. Risk factors of non-tuberculous mycobacteria infection are severe immunologic defects and structural abnormalities. Lung transplant recipients are at higher risk for non-tuberculous mycobacterial disease compared to recipients of other solid organs. The clinical presentation could be skin and soft tissue infection, osteoarticular disease, pleuropulmonary infection, bloodstream (including catheter-associated) infection, lymphadenitis, and disseminated or multi-organ disease. Management of non-tuberculous mycobacteria infection is complex due to the prolonged treatment course with multi-drug regimens that are anticipated to interact with immunosuppressive medications. This review article provides an update on infections due to non-tuberculous mycobacteria after solid organ transplantation, and discusses the epidemiology, risk factors, clinical presentation, and management.
AB - Non-tuberculous mycobacteria are ubiquitous environmental organisms that are now increasingly recognized as important causes of clinical disease in solid organ transplant recipients. Risk factors of non-tuberculous mycobacteria infection are severe immunologic defects and structural abnormalities. Lung transplant recipients are at higher risk for non-tuberculous mycobacterial disease compared to recipients of other solid organs. The clinical presentation could be skin and soft tissue infection, osteoarticular disease, pleuropulmonary infection, bloodstream (including catheter-associated) infection, lymphadenitis, and disseminated or multi-organ disease. Management of non-tuberculous mycobacteria infection is complex due to the prolonged treatment course with multi-drug regimens that are anticipated to interact with immunosuppressive medications. This review article provides an update on infections due to non-tuberculous mycobacteria after solid organ transplantation, and discusses the epidemiology, risk factors, clinical presentation, and management.
KW - Drug interactions
KW - Lung transplantation
KW - Mycobacteria
KW - Pneumonia
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=84967019381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84967019381&partnerID=8YFLogxK
U2 - 10.1016/j.jctube.2016.04.001
DO - 10.1016/j.jctube.2016.04.001
M3 - Article
AN - SCOPUS:84967019381
VL - 4
SP - 1
EP - 8
JO - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
JF - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
SN - 2405-5794
ER -