Non-tuberculous mycobacterial infections in solid organ transplant recipients: An update

Cybele L. Abad, Raymund R Razonable

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Non-tuberculous mycobacteria are ubiquitous environmental organisms that are now increasingly recognized as important causes of clinical disease in solid organ transplant recipients. Risk factors of non-tuberculous mycobacteria infection are severe immunologic defects and structural abnormalities. Lung transplant recipients are at higher risk for non-tuberculous mycobacterial disease compared to recipients of other solid organs. The clinical presentation could be skin and soft tissue infection, osteoarticular disease, pleuropulmonary infection, bloodstream (including catheter-associated) infection, lymphadenitis, and disseminated or multi-organ disease. Management of non-tuberculous mycobacteria infection is complex due to the prolonged treatment course with multi-drug regimens that are anticipated to interact with immunosuppressive medications. This review article provides an update on infections due to non-tuberculous mycobacteria after solid organ transplantation, and discusses the epidemiology, risk factors, clinical presentation, and management.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Clinical Tuberculosis and Other Mycobacterial Diseases
Volume4
DOIs
StatePublished - Aug 1 2016

Fingerprint

Transplants
Mycobacterium Infections
Mycobacterium
Infection
Catheter-Related Infections
Lymphadenitis
Soft Tissue Infections
Organ Transplantation
Immunosuppressive Agents
Epidemiology
Lung
Skin
Transplant Recipients
Pharmaceutical Preparations
Therapeutics

Keywords

  • Drug interactions
  • Lung transplantation
  • Mycobacteria
  • Pneumonia
  • Transplantation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases
  • Microbiology (medical)

Cite this

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