TY - JOUR
T1 - Non-small-cell lung cancer in elderly patients
T2 - A discussion of treatment options
AU - Gajra, Ajeet
AU - Jatoi, Aminah
PY - 2014/8/20
Y1 - 2014/8/20
N2 - Lung cancer is a disease of the elderly. In older patients, the management of a malignancy as complex and potentially as lethal as lung cancer is challenging. Despite the fact that a large proportion of patients with non-small-cell lung cancer are elderly, information remains scant on how best to treat these patients. The goal of this review is to discuss the published literature and to provide guidance on how to treat elderly patients within three broad stages: (1) metastatic cancer, (2) early-stage cancer after surgery, and (3) locally advanced inoperable cancer. Because decisions on how and when to prescribe systemic treatment can be particularly difficult, this review focuses heavily on chemotherapy-related treatment decisions with some discussion of emerging data on the use of the comprehensive geriatric assessment.
AB - Lung cancer is a disease of the elderly. In older patients, the management of a malignancy as complex and potentially as lethal as lung cancer is challenging. Despite the fact that a large proportion of patients with non-small-cell lung cancer are elderly, information remains scant on how best to treat these patients. The goal of this review is to discuss the published literature and to provide guidance on how to treat elderly patients within three broad stages: (1) metastatic cancer, (2) early-stage cancer after surgery, and (3) locally advanced inoperable cancer. Because decisions on how and when to prescribe systemic treatment can be particularly difficult, this review focuses heavily on chemotherapy-related treatment decisions with some discussion of emerging data on the use of the comprehensive geriatric assessment.
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U2 - 10.1200/JCO.2014.55.3099
DO - 10.1200/JCO.2014.55.3099
M3 - Review article
C2 - 25071101
AN - SCOPUS:84906213414
SN - 0732-183X
VL - 32
SP - 2562
EP - 2569
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 24
ER -