Non-neurogenic inhibitory effect of electrical impulses in isolated canine coronary arteries

Thom W Rooke, R. A. Cohen, T. J. Verbeuren, P. M. VanHoutte

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Electrical stimulation caused frequency-dependent reversible relaxations of canine coronary arteries made to contract with prostaglandin F, phenylephrine, 5-hydroxytryptamine, potassium chloride, or angiotensin II. These contractions were not affected by cold storage, tetrodotoxin, α- and β-adrenergic blockade and atropine, demonstrating that they probably are not due to activation of inhibitory nerves. The relaxations persisted in the presence of indomethacin and after removal of the endothelium. They were not seen in splenic arteries and saphenous veins, demonstrating the high sensitivity of the coronary blood vessel wall to the inhibitory effects of the electric impulses.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalEuropean Journal of Pharmacology
Volume80
Issue number2-3
DOIs
StatePublished - May 21 1982

Fingerprint

Canidae
Coronary Vessels
Splenic Vein
Splenic Artery
Dinoprost
Potassium Chloride
Saphenous Vein
Tetrodotoxin
Phenylephrine
Atropine
Indomethacin
Angiotensin II
Adrenergic Agents
Electric Stimulation
Endothelium
Blood Vessels
Serotonin

Keywords

  • Coronary smooth muscle
  • Electrical stimulation
  • Inhibitory vasodilator nerves

ASJC Scopus subject areas

  • Pharmacology

Cite this

Non-neurogenic inhibitory effect of electrical impulses in isolated canine coronary arteries. / Rooke, Thom W; Cohen, R. A.; Verbeuren, T. J.; VanHoutte, P. M.

In: European Journal of Pharmacology, Vol. 80, No. 2-3, 21.05.1982, p. 251-254.

Research output: Contribution to journalArticle

Rooke, Thom W ; Cohen, R. A. ; Verbeuren, T. J. ; VanHoutte, P. M. / Non-neurogenic inhibitory effect of electrical impulses in isolated canine coronary arteries. In: European Journal of Pharmacology. 1982 ; Vol. 80, No. 2-3. pp. 251-254.
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