Non-neurogenic inhibitory effect of electrical impulses in isolated canine coronary arteries

T. Rooke, R. A. Cohen, T. J. Verbeuren, P. M. VanHoutte

Research output: Contribution to journalArticle

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Abstract

Electrical stimulation caused frequency-dependent reversible relaxations of canine coronary arteries made to contract with prostaglandin F, phenylephrine, 5-hydroxytryptamine, potassium chloride, or angiotensin II. These contractions were not affected by cold storage, tetrodotoxin, α- and β-adrenergic blockade and atropine, demonstrating that they probably are not due to activation of inhibitory nerves. The relaxations persisted in the presence of indomethacin and after removal of the endothelium. They were not seen in splenic arteries and saphenous veins, demonstrating the high sensitivity of the coronary blood vessel wall to the inhibitory effects of the electric impulses.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalEuropean Journal of Pharmacology
Volume80
Issue number2-3
DOIs
StatePublished - May 21 1982

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Keywords

  • Coronary smooth muscle
  • Electrical stimulation
  • Inhibitory vasodilator nerves

ASJC Scopus subject areas

  • Pharmacology

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