TY - JOUR
T1 - Non-neurogenic inhibitory effect of electrical impulses in isolated canine coronary arteries
AU - Rooke, T.
AU - Cohen, R. A.
AU - Verbeuren, T. J.
AU - VanHoutte, P. M.
N1 - Funding Information:
* Supported in part by grant HL05883 from the National Institutes of Health. ** To whom all correspondence should be addressed: Depart-ment of Physiology and Biophysics, Mayo Clinic, Roches-ter, MN 55905, U.S.A.
PY - 1982/5/21
Y1 - 1982/5/21
N2 - Electrical stimulation caused frequency-dependent reversible relaxations of canine coronary arteries made to contract with prostaglandin F2α, phenylephrine, 5-hydroxytryptamine, potassium chloride, or angiotensin II. These contractions were not affected by cold storage, tetrodotoxin, α- and β-adrenergic blockade and atropine, demonstrating that they probably are not due to activation of inhibitory nerves. The relaxations persisted in the presence of indomethacin and after removal of the endothelium. They were not seen in splenic arteries and saphenous veins, demonstrating the high sensitivity of the coronary blood vessel wall to the inhibitory effects of the electric impulses.
AB - Electrical stimulation caused frequency-dependent reversible relaxations of canine coronary arteries made to contract with prostaglandin F2α, phenylephrine, 5-hydroxytryptamine, potassium chloride, or angiotensin II. These contractions were not affected by cold storage, tetrodotoxin, α- and β-adrenergic blockade and atropine, demonstrating that they probably are not due to activation of inhibitory nerves. The relaxations persisted in the presence of indomethacin and after removal of the endothelium. They were not seen in splenic arteries and saphenous veins, demonstrating the high sensitivity of the coronary blood vessel wall to the inhibitory effects of the electric impulses.
KW - Coronary smooth muscle
KW - Electrical stimulation
KW - Inhibitory vasodilator nerves
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U2 - 10.1016/0014-2999(82)90063-2
DO - 10.1016/0014-2999(82)90063-2
M3 - Article
C2 - 7106182
AN - SCOPUS:0020054023
SN - 0014-2999
VL - 80
SP - 251
EP - 254
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -