TY - JOUR
T1 - Non-motor symptoms in atypical and secondary parkinsonism
T2 - The PRIAMO study
AU - PRIAMO Study Group
AU - Colosimo, Carlo
AU - Morgante, Letterio
AU - Antonini, Angelo
AU - Barone, Paolo
AU - Avarello, Tania P.
AU - Bottacchi, Edo
AU - Cannas, Antonino
AU - Ceravolo, Maria Gabriella
AU - Ceravolo, Roberto
AU - Cicarelli, Giulio
AU - Gaglio, Rosa M.
AU - Giglia, Luisa
AU - Iemolo, Francesco
AU - Manfredi, Michela
AU - Meco, Giuseppe
AU - Nicoletti, Alessandra
AU - Pederzoli, Massimo
AU - Petrone, Alfredo
AU - Pisani, Antonio
AU - Pontieri, Francesco E.
AU - Quatrale, Rocco
AU - Ramat, Silvia
AU - Scala, Rossana
AU - Volpe, Giampiero
AU - Zappulla, Salvatore
AU - Bentivoglio, Anna Rita
AU - Stocchi, Fabrizio
AU - Trianni, Giorgio
AU - Del Dotto, Paolo
AU - Simoni, Lucia
AU - Marconi, Roberto
AU - Benincasa, D.
AU - Biguzzi, S.
AU - Braga, M.
AU - Capecci, M.
AU - Caravona, N.
AU - D’asta, G.
AU - De Falco, F. A.
AU - De Gaspari, D.
AU - Pezzoli, G.
AU - Di Giovanni, M.
AU - Floris, G.
AU - Gallerini, S.
AU - Grasso, L.
AU - Gurgone, G.
AU - Kiferle, L.
AU - Meoni, S.
AU - Morgante, F.
AU - Savica, R.
AU - Moschella, V.
N1 - Funding Information:
This study was supported by an educational grant issued by Boehringer-Ingelheim, Italy. L. Simoni is an employee of Medidata s.r.l.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.
AB - The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.
KW - Atypical parkinsonism
KW - Non-motor symptoms
KW - Parkinson and cognitive impairment
KW - Secondary parkinsonism
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UR - http://www.scopus.com/inward/citedby.url?scp=74849129545&partnerID=8YFLogxK
U2 - 10.1007/s00415-009-5255-7
DO - 10.1007/s00415-009-5255-7
M3 - Article
C2 - 19669613
AN - SCOPUS:74849129545
SN - 0340-5354
VL - 257
SP - 5
EP - 14
JO - Deutsche Zeitschrift fur Nervenheilkunde
JF - Deutsche Zeitschrift fur Nervenheilkunde
IS - 1
ER -