Non-infarct related artery microvascular obstruction is associated with worse persistent diastolic dysfunction in patients with revascularized ST elevation myocardial infarction

Michel T. Corban, Reza Khorramirouz, Shi Wei Yang, Bradley R. Lewis, John Bois, Thomas Foley, Lilach O. Lerman, Jae k. Oh, Amir Lerman

Research output: Contribution to journalArticle

1 Scopus citations


Revascularized STEMI patients with baseline concurrent infarct related coronary artery (IRA) and nonIRA microvascular obstruction (MVO) [IRA + nonIRA+], as compared to IRA + nonIRA- MVO patients, had higher prevalence of diastolic dysfunction at baseline (40.7 vs. 6.1%, p = 0.006) and 4 years follow-up (50.0 vs. 13.0%, p = 0.05). The prevalence of grade 1 diastolic dysfunction increased (60.9–73.9%) and combined grades 2 and 3 decreased (30.4–13.0%) at follow up in patients with IRA + nonIRA- MVO. In contrast, grade 1 diastolic dysfunction decreased (77.8–61.1%) and combined grades 2 and 3 increased (8.3–22.2%) at follow up in patients with IRA + nonIRA + MVO.

Original languageEnglish (US)
JournalInternational Journal of Cardiology
StateAccepted/In press - Jan 1 2019



  • Coronary microvascular obstruction
  • Diastolic dysfunction
  • Non-infarct related coronary artery
  • ST-elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this