Non-infarct related artery microvascular obstruction is associated with worse persistent diastolic dysfunction in patients with revascularized ST elevation myocardial infarction

Michel T. Corban, Reza Khorramirouz, Shi Wei Yang, Bradley R. Lewis, John Bois, Thomas Foley, Lilach O. Lerman, Jae k. Oh, Amir Lerman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Revascularized STEMI patients with baseline concurrent infarct related coronary artery (IRA) and nonIRA microvascular obstruction (MVO) [IRA + nonIRA+], as compared to IRA + nonIRA- MVO patients, had higher prevalence of diastolic dysfunction at baseline (40.7 vs. 6.1%, p = 0.006) and 4 years follow-up (50.0 vs. 13.0%, p = 0.05). The prevalence of grade 1 diastolic dysfunction increased (60.9–73.9%) and combined grades 2 and 3 decreased (30.4–13.0%) at follow up in patients with IRA + nonIRA- MVO. In contrast, grade 1 diastolic dysfunction decreased (77.8–61.1%) and combined grades 2 and 3 increased (8.3–22.2%) at follow up in patients with IRA + nonIRA + MVO.

Original languageEnglish (US)
JournalInternational Journal of Cardiology
DOIs
StateAccepted/In press - Jan 1 2019

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Coronary Vessels
Arteries
ST Elevation Myocardial Infarction

Keywords

  • Coronary microvascular obstruction
  • Diastolic dysfunction
  • Non-infarct related coronary artery
  • ST-elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Non-infarct related artery microvascular obstruction is associated with worse persistent diastolic dysfunction in patients with revascularized ST elevation myocardial infarction. / Corban, Michel T.; Khorramirouz, Reza; Yang, Shi Wei; Lewis, Bradley R.; Bois, John; Foley, Thomas; Lerman, Lilach O.; Oh, Jae k.; Lerman, Amir.

In: International Journal of Cardiology, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Revascularized STEMI patients with baseline concurrent infarct related coronary artery (IRA) and nonIRA microvascular obstruction (MVO) [IRA + nonIRA+], as compared to IRA + nonIRA- MVO patients, had higher prevalence of diastolic dysfunction at baseline (40.7 vs. 6.1{\%}, p = 0.006) and 4 years follow-up (50.0 vs. 13.0{\%}, p = 0.05). The prevalence of grade 1 diastolic dysfunction increased (60.9–73.9{\%}) and combined grades 2 and 3 decreased (30.4–13.0{\%}) at follow up in patients with IRA + nonIRA- MVO. In contrast, grade 1 diastolic dysfunction decreased (77.8–61.1{\%}) and combined grades 2 and 3 increased (8.3–22.2{\%}) at follow up in patients with IRA + nonIRA + MVO.",
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author = "Corban, {Michel T.} and Reza Khorramirouz and Yang, {Shi Wei} and Lewis, {Bradley R.} and John Bois and Thomas Foley and Lerman, {Lilach O.} and Oh, {Jae k.} and Amir Lerman",
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AU - Corban, Michel T.

AU - Khorramirouz, Reza

AU - Yang, Shi Wei

AU - Lewis, Bradley R.

AU - Bois, John

AU - Foley, Thomas

AU - Lerman, Lilach O.

AU - Oh, Jae k.

AU - Lerman, Amir

PY - 2019/1/1

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N2 - Revascularized STEMI patients with baseline concurrent infarct related coronary artery (IRA) and nonIRA microvascular obstruction (MVO) [IRA + nonIRA+], as compared to IRA + nonIRA- MVO patients, had higher prevalence of diastolic dysfunction at baseline (40.7 vs. 6.1%, p = 0.006) and 4 years follow-up (50.0 vs. 13.0%, p = 0.05). The prevalence of grade 1 diastolic dysfunction increased (60.9–73.9%) and combined grades 2 and 3 decreased (30.4–13.0%) at follow up in patients with IRA + nonIRA- MVO. In contrast, grade 1 diastolic dysfunction decreased (77.8–61.1%) and combined grades 2 and 3 increased (8.3–22.2%) at follow up in patients with IRA + nonIRA + MVO.

AB - Revascularized STEMI patients with baseline concurrent infarct related coronary artery (IRA) and nonIRA microvascular obstruction (MVO) [IRA + nonIRA+], as compared to IRA + nonIRA- MVO patients, had higher prevalence of diastolic dysfunction at baseline (40.7 vs. 6.1%, p = 0.006) and 4 years follow-up (50.0 vs. 13.0%, p = 0.05). The prevalence of grade 1 diastolic dysfunction increased (60.9–73.9%) and combined grades 2 and 3 decreased (30.4–13.0%) at follow up in patients with IRA + nonIRA- MVO. In contrast, grade 1 diastolic dysfunction decreased (77.8–61.1%) and combined grades 2 and 3 increased (8.3–22.2%) at follow up in patients with IRA + nonIRA + MVO.

KW - Coronary microvascular obstruction

KW - Diastolic dysfunction

KW - Non-infarct related coronary artery

KW - ST-elevation myocardial infarction

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