Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: Utility of fluorescence in situ hybridization (FISH) in a case-control study

Cindy M. Chang, Jane C. Schroeder, Wen Yi Huang, Cherie H. Dunphy, Ralph S. Baric, Andrew F. Olshan, Kathleen C. Dorsey, Georgette A. Dent, James R. Cerhan, Charles F. Lynch, Nathaniel Rothman, Kenneth P. Cantor, Aaron Blair

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalLeukemia Research
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2010

Keywords

  • FISH
  • Lymphoma
  • Translocation
  • bcl-2
  • t(14 ;18)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Chang, C. M., Schroeder, J. C., Huang, W. Y., Dunphy, C. H., Baric, R. S., Olshan, A. F., Dorsey, K. C., Dent, G. A., Cerhan, J. R., Lynch, C. F., Rothman, N., Cantor, K. P., & Blair, A. (2010). Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: Utility of fluorescence in situ hybridization (FISH) in a case-control study. Leukemia Research, 34(2), 190-195. https://doi.org/10.1016/j.leukres.2009.05.007