@article{2c8858a2178a4add8d92a770fa073a31,
title = "Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: Utility of fluorescence in situ hybridization (FISH) in a case-control study",
abstract = "We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.",
keywords = "FISH, Lymphoma, Translocation, bcl-2, t(14 ;18)",
author = "Chang, {Cindy M.} and Schroeder, {Jane C.} and Huang, {Wen Yi} and Dunphy, {Cherie H.} and Baric, {Ralph S.} and Olshan, {Andrew F.} and Dorsey, {Kathleen C.} and Dent, {Georgette A.} and Cerhan, {James R.} and Lynch, {Charles F.} and Nathaniel Rothman and Cantor, {Kenneth P.} and Aaron Blair",
note = "Funding Information: This study was supported in part by the UNC Lineberger Comprehensive Cancer Center (Population Sciences Research Award), the National Institute of Environmental Health Sciences (P30ES10126), the National Institutes of Health, National Cancer Institute (R03 CA71617-01), and the NIH Intramural Research Program (Division of Cancer Epidemiology and Genetics, National Cancer Institute). Special thanks to Sophia Wang and Charles Rabkin for their helpful comments, David W. Cowan from the Lineberger Comprehensive Cancer Center Immunohistochemistry/Hybridization Core Laboratory for guidance with FISH assays; Stephen Oglesbee and Boyd Yount from UNC-Chapel Hill; and Paige Tolbert from Emory University. ",
year = "2010",
month = feb,
doi = "10.1016/j.leukres.2009.05.007",
language = "English (US)",
volume = "34",
pages = "190--195",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "2",
}