Non-Hodgkin lymphoma, body mass index, and cytokine polymorphisms: A pooled analysis from the interlymph consortium

Eleanor Kane, Christine F. Skibola, Paige M. Bracci, James R Cerhan, Laura Costas, Karin Ekström Smedby, Elizabeth A. Holly, Marc Maynadié, Anne J Novak, Tracy J. Lightfoot, Stephen Maxted Ansell, Alex G. Smith, Mark Liebow, Mads Melbye, Lindsay Morton, Silvia De Sanjosé, Susan L Slager, Sophia S. Wang, Yawei Zhang, Tongzhang ZhengEve Roman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported. Method: Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI). Results: Obesity (BMI≥30 kg/m2) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GAAA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GAAA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05- 0.84; Pinteraction =0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GAAA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected. Conclusions: Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GAAA may interact to increase DLBCL risk. Impact: Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.

Original languageEnglish (US)
Pages (from-to)1061-1070
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number7
DOIs
StatePublished - Jul 1 2015

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Non-Hodgkin's Lymphoma
Body Mass Index
Lymphoma, Large B-Cell, Diffuse
Obesity
B-Cell Chronic Lymphocytic Leukemia
Cytokines
Confidence Intervals
Follicular Lymphoma
Adiposity
Lymphoma
Weights and Measures
Interleukin-10
Interleukin-2
Interleukin-6
B-Lymphocytes
Logistic Models
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Non-Hodgkin lymphoma, body mass index, and cytokine polymorphisms : A pooled analysis from the interlymph consortium. / Kane, Eleanor; Skibola, Christine F.; Bracci, Paige M.; Cerhan, James R; Costas, Laura; Smedby, Karin Ekström; Holly, Elizabeth A.; Maynadié, Marc; Novak, Anne J; Lightfoot, Tracy J.; Ansell, Stephen Maxted; Smith, Alex G.; Liebow, Mark; Melbye, Mads; Morton, Lindsay; De Sanjosé, Silvia; Slager, Susan L; Wang, Sophia S.; Zhang, Yawei; Zheng, Tongzhang; Roman, Eve.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 7, 01.07.2015, p. 1061-1070.

Research output: Contribution to journalArticle

Kane, E, Skibola, CF, Bracci, PM, Cerhan, JR, Costas, L, Smedby, KE, Holly, EA, Maynadié, M, Novak, AJ, Lightfoot, TJ, Ansell, SM, Smith, AG, Liebow, M, Melbye, M, Morton, L, De Sanjosé, S, Slager, SL, Wang, SS, Zhang, Y, Zheng, T & Roman, E 2015, 'Non-Hodgkin lymphoma, body mass index, and cytokine polymorphisms: A pooled analysis from the interlymph consortium', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 7, pp. 1061-1070. https://doi.org/10.1158/1055-9965.EPI-14-1355
Kane, Eleanor ; Skibola, Christine F. ; Bracci, Paige M. ; Cerhan, James R ; Costas, Laura ; Smedby, Karin Ekström ; Holly, Elizabeth A. ; Maynadié, Marc ; Novak, Anne J ; Lightfoot, Tracy J. ; Ansell, Stephen Maxted ; Smith, Alex G. ; Liebow, Mark ; Melbye, Mads ; Morton, Lindsay ; De Sanjosé, Silvia ; Slager, Susan L ; Wang, Sophia S. ; Zhang, Yawei ; Zheng, Tongzhang ; Roman, Eve. / Non-Hodgkin lymphoma, body mass index, and cytokine polymorphisms : A pooled analysis from the interlymph consortium. In: Cancer Epidemiology Biomarkers and Prevention. 2015 ; Vol. 24, No. 7. pp. 1061-1070.
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abstract = "Background: Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported. Method: Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI). Results: Obesity (BMI≥30 kg/m2) was associated with DLBCL risk [OR = 1.33; 95{\%} confidence interval (CI), 1.02-1.73], as was TNF-308GAAA (OR = 1.24; 95{\%} CI, 1.07-1.44). Together, being obese and TNF-308GAAA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95{\%} CI, 1.27-2.94), with a RERI of 0.41 (95{\%} CI, -0.05- 0.84; Pinteraction =0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GAAA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected. Conclusions: Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GAAA may interact to increase DLBCL risk. Impact: Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.",
author = "Eleanor Kane and Skibola, {Christine F.} and Bracci, {Paige M.} and Cerhan, {James R} and Laura Costas and Smedby, {Karin Ekstr{\"o}m} and Holly, {Elizabeth A.} and Marc Maynadi{\'e} and Novak, {Anne J} and Lightfoot, {Tracy J.} and Ansell, {Stephen Maxted} and Smith, {Alex G.} and Mark Liebow and Mads Melbye and Lindsay Morton and {De Sanjos{\'e}}, Silvia and Slager, {Susan L} and Wang, {Sophia S.} and Yawei Zhang and Tongzhang Zheng and Eve Roman",
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T1 - Non-Hodgkin lymphoma, body mass index, and cytokine polymorphisms

T2 - A pooled analysis from the interlymph consortium

AU - Kane, Eleanor

AU - Skibola, Christine F.

AU - Bracci, Paige M.

AU - Cerhan, James R

AU - Costas, Laura

AU - Smedby, Karin Ekström

AU - Holly, Elizabeth A.

AU - Maynadié, Marc

AU - Novak, Anne J

AU - Lightfoot, Tracy J.

AU - Ansell, Stephen Maxted

AU - Smith, Alex G.

AU - Liebow, Mark

AU - Melbye, Mads

AU - Morton, Lindsay

AU - De Sanjosé, Silvia

AU - Slager, Susan L

AU - Wang, Sophia S.

AU - Zhang, Yawei

AU - Zheng, Tongzhang

AU - Roman, Eve

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background: Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported. Method: Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI). Results: Obesity (BMI≥30 kg/m2) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GAAA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GAAA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05- 0.84; Pinteraction =0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GAAA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected. Conclusions: Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GAAA may interact to increase DLBCL risk. Impact: Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.

AB - Background: Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported. Method: Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI). Results: Obesity (BMI≥30 kg/m2) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GAAA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GAAA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05- 0.84; Pinteraction =0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GAAA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected. Conclusions: Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GAAA may interact to increase DLBCL risk. Impact: Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.

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