TY - JOUR
T1 - Non-Hodgkin lymphoma, body mass index, and cytokine polymorphisms
T2 - A pooled analysis from the interlymph consortium
AU - Kane, Eleanor
AU - Skibola, Christine F.
AU - Bracci, Paige M.
AU - Cerhan, James R.
AU - Costas, Laura
AU - Smedby, Karin Ekström
AU - Holly, Elizabeth A.
AU - Maynadié, Marc
AU - Novak, Anne J.
AU - Lightfoot, Tracy J.
AU - Ansell, Stephen M.
AU - Smith, Alex G.
AU - Liebow, Mark
AU - Melbye, Mads
AU - Morton, Lindsay
AU - De Sanjosé, Silvia
AU - Slager, Susan L.
AU - Wang, Sophia S.
AU - Zhang, Yawei
AU - Zheng, Tongzhang
AU - Roman, Eve
N1 - Publisher Copyright:
© 2015 American Association for Cancer Research.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background: Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported. Method: Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI). Results: Obesity (BMI≥30 kg/m2) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GAAA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GAAA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05- 0.84; Pinteraction =0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GAAA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected. Conclusions: Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GAAA may interact to increase DLBCL risk. Impact: Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.
AB - Background: Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported. Method: Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI). Results: Obesity (BMI≥30 kg/m2) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GAAA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GAAA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05- 0.84; Pinteraction =0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GAAA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected. Conclusions: Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GAAA may interact to increase DLBCL risk. Impact: Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.
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U2 - 10.1158/1055-9965.EPI-14-1355
DO - 10.1158/1055-9965.EPI-14-1355
M3 - Article
C2 - 25962811
AN - SCOPUS:84941781531
SN - 1055-9965
VL - 24
SP - 1061
EP - 1070
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 7
ER -