Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Marcel Klingenberg, Akiko Matsuda, Sven Diederichs, Tushar Patel

Research output: Contribution to journalReview articlepeer-review

152 Scopus citations

Abstract

The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.

Original languageEnglish (US)
Pages (from-to)603-618
Number of pages16
JournalJournal of hepatology
Volume67
Issue number3
DOIs
StatePublished - Sep 2017

Keywords

  • Cancer stem cell
  • Epithelial–to-mesenchymal transition
  • HCC
  • Hepatocellular carcinoma
  • Liver cancer
  • Long non-coding RNA
  • STAT3
  • Wnt
  • lncRNA
  • microRNA

ASJC Scopus subject areas

  • Hepatology

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