Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Marcel Klingenberg; Akiko Matsuda; Sven Diederichs; Tushar Patel

doi:10.1016/j.jhep.2017.04.009

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Marcel Klingenberg, Akiko Matsuda, Sven Diederichs, Tushar Patel

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

184 Scopus citations

Abstract

The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.

Original language	English (US)
Pages (from-to)	603-618
Number of pages	16
Journal	Journal of hepatology
Volume	67
Issue number	3
DOIs	https://doi.org/10.1016/j.jhep.2017.04.009
State	Published - Sep 2017

Keywords

Cancer stem cell
Epithelial–to-mesenchymal transition
HCC
Hepatocellular carcinoma
Liver cancer
Long non-coding RNA
STAT3
Wnt
lncRNA
microRNA

ASJC Scopus subject areas

Hepatology

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10.1016/j.jhep.2017.04.009

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title = "Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets",

abstract = "The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.",

keywords = "Cancer stem cell, Epithelial–to-mesenchymal transition, HCC, Hepatocellular carcinoma, Liver cancer, Long non-coding RNA, STAT3, Wnt, lncRNA, microRNA",

author = "Marcel Klingenberg and Akiko Matsuda and Sven Diederichs and Tushar Patel",

note = "Publisher Copyright: {\textcopyright} 2017 European Association for the Study of the Liver",

year = "2017",

month = sep,

doi = "10.1016/j.jhep.2017.04.009",

language = "English (US)",

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T1 - Non-coding RNA in hepatocellular carcinoma

T2 - Mechanisms, biomarkers and therapeutic targets

AU - Klingenberg, Marcel

AU - Matsuda, Akiko

AU - Diederichs, Sven

AU - Patel, Tushar

PY - 2017/9

Y1 - 2017/9

N2 - The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.

AB - The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.

KW - Cancer stem cell

KW - Epithelial–to-mesenchymal transition

KW - HCC

KW - Hepatocellular carcinoma

KW - Liver cancer

KW - Long non-coding RNA

KW - STAT3

KW - Wnt

KW - lncRNA

KW - microRNA

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U2 - 10.1016/j.jhep.2017.04.009

DO - 10.1016/j.jhep.2017.04.009

M3 - Review article

C2 - 28438689

AN - SCOPUS:85020090668

SN - 0168-8278

VL - 67

SP - 603

EP - 618

JO - Journal of hepatology

JF - Journal of hepatology

IS - 3

ER -

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Abstract

Keywords

ASJC Scopus subject areas

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