Non-celiac gluten hypersensitivity: What is all the fuss about?

Steffen Husby, Joseph A Murray

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Non-celiac gluten sensitivity (NCGS) has been introduced recently as a potentially common disease on the basis of studies of patients with claimed reactivity to gluten but without the characteristics of celiac disease (CD). CD is characterized by antibody reactivity toward the autoantigen transglutaminase 2, characteristic histological abnormalities of the small intestine, and an almost obligatory genetic haplotype (HLA-DQ2 or DQ8). The diagnosis of NCGS is based largely on the clinical suspicion of hyper-reactivity to gluten and the absence of the characteristics of CD. Few published studies have used double-blind placebo-controlled food challenges (DBPCFCs) for the diagnosis of NCGS, and none in children. Innate immune reactivity to amylase trypsin inhibitors has been suggested as the pathogenic principle in NCGS, but confirmatory evidence is lacking. Also, further clinical studies including DBPCFCs are needed.

Original languageEnglish (US)
Article number54
JournalF1000Prime Reports
Volume7
DOIs
StatePublished - May 12 2015

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Non-celiac gluten hypersensitivity: What is all the fuss about?'. Together they form a unique fingerprint.

  • Cite this