Nodular Fasciitis: False Positive on 18F-Piflufolastat and 11C-Choline PET/CT

Marika A. Pitot, Stephen M. Broski, Scott M. Thompson, David A. Woodrum, Garret M. Powell

Research output: Contribution to journalArticlepeer-review


PET/CT plays a crucial role in the management of prostate cancer with several emerging and established radiopharmaceuticals, including 18F-piflufolastat and 11C-choline. These radiotracers are thought to be relatively specific to prostate cancer; however, uptake has also been demonstrated in other benign and malignant lesions. Nodular fasciitis is a rapidly growing benign soft tissue neoplasm that is typically self-limiting. Although a few case reports describe 68Ga-PSMA uptake in nodular fasciitis, uptake of 11C-choline and other PSMA-targeted PET probes, including 18F-piflufolastat, have not previously been reported. We present a novel case of nodular fasciitis demonstrating both 18F-piflufolastat and 11C-choline avidity.

Original languageEnglish (US)
Pages (from-to)E209-E211
JournalClinical nuclear medicine
Issue number4
StatePublished - Apr 1 2023


  • PSMA
  • choline
  • nodular fasciitis
  • piflufolastat

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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