Nodular amiodarone lung disease

Ruchira Ruangchira-Urai, Thomas V. Colby, Julianne Klein, G. Petur Nielsen, Richard L. Kradin, Eugene J. Mark

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The antiarrhythmic drug amiodarone accumulates in many organs of the body. Amiodarone lung disease (ALD) most commonly manifests clinically as an interstitial pneumonitis. The few reports of nodular ALD generally have been in the clinical and radiographic literature. No detailed histopathologic analysis of nodular ALD is available. We report 4 patients with nodular ALD, all of whom had excision of a nodule and none had a preoperative diagnosis of ALD. The radiographic suspicion before excisional biopsy in all 4 cases was malignancy. The initial pathologic suspicion in all 4 cases was either an abscess or vasculitis. In 3 of the 4 cases, where the dosages were known, each patient received 800mg/d for 7 or more months. All cases have strikingly similar histopathology, with vacuolated histiocytes massed within alveoli to form macroscopic nodules with tissue breakdown. Ultrastructural examination of lung and peripheral nerve in 1 case showed the characteristic inclusions of amiodarone in the cytoplasm of swollen histiocytes. Vacuolated histiocytes filled with these inclusions indicate the effect of the drug, but in these 4 cases there was tissue destruction, which indicated disease. The necrotizing nature of the massed histiocytes in the absence of infection or obstruction suggests the correct etiologic diagnosis even when the history of administration of the drug is not available at initial review.

Original languageEnglish (US)
Pages (from-to)1654-1660
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume32
Issue number11
DOIs
StatePublished - Nov 2008

Fingerprint

Amiodarone
Lung Diseases
Histiocytes
Anti-Arrhythmia Agents
Interstitial Lung Diseases
Vasculitis
Peripheral Nerves
Pharmaceutical Preparations
Abscess
Cytoplasm
History
Biopsy
Lung
Infection
Neoplasms

Keywords

  • Amiodarone
  • Drug pneumonitis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

Cite this

Ruangchira-Urai, R., Colby, T. V., Klein, J., Nielsen, G. P., Kradin, R. L., & Mark, E. J. (2008). Nodular amiodarone lung disease. American Journal of Surgical Pathology, 32(11), 1654-1660. https://doi.org/10.1097/PAS.0b013e31816d1cbc

Nodular amiodarone lung disease. / Ruangchira-Urai, Ruchira; Colby, Thomas V.; Klein, Julianne; Nielsen, G. Petur; Kradin, Richard L.; Mark, Eugene J.

In: American Journal of Surgical Pathology, Vol. 32, No. 11, 11.2008, p. 1654-1660.

Research output: Contribution to journalArticle

Ruangchira-Urai, R, Colby, TV, Klein, J, Nielsen, GP, Kradin, RL & Mark, EJ 2008, 'Nodular amiodarone lung disease', American Journal of Surgical Pathology, vol. 32, no. 11, pp. 1654-1660. https://doi.org/10.1097/PAS.0b013e31816d1cbc
Ruangchira-Urai R, Colby TV, Klein J, Nielsen GP, Kradin RL, Mark EJ. Nodular amiodarone lung disease. American Journal of Surgical Pathology. 2008 Nov;32(11):1654-1660. https://doi.org/10.1097/PAS.0b013e31816d1cbc
Ruangchira-Urai, Ruchira ; Colby, Thomas V. ; Klein, Julianne ; Nielsen, G. Petur ; Kradin, Richard L. ; Mark, Eugene J. / Nodular amiodarone lung disease. In: American Journal of Surgical Pathology. 2008 ; Vol. 32, No. 11. pp. 1654-1660.
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