No differences in manic-like behaviors between voluntary ethanol and water drinking in Lateral Hypothalamic Kindled (LHK) alcohol preferring rats

Noha Abdel Gawad; Khalid Mohamed; Doo Sup Choi; Osama A. Abulseoud

doi:10.1016/j.psychres.2017.12.075

No differences in manic-like behaviors between voluntary ethanol and water drinking in Lateral Hypothalamic Kindled (LHK) alcohol preferring rats

Noha Abdel Gawad, Khalid Mohamed, Doo Sup Choi, Osama A. Abulseoud

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigates phenotypic differences of manic-like behaviors during voluntary ethanol (vs. water) intake in alcohol preferring (P) rats, using the lateral hypothalamus kindled (LHK) rat mania model. Alcohol preferring (P) rats exhibited classic manic-like behaviors during kindling and the post-kindling intervals in all coded behaviors (p < 0.0001), lending further validity to the lateral hypothalamus kindled rat as a useful model to study mania. However, there was no significant phenotypic difference between alcohol and water drinking alcohol preferring (P) rats.

Original language	English (US)
Pages (from-to)	186-189
Number of pages	4
Journal	Psychiatry Research
Volume	261
DOIs	https://doi.org/10.1016/j.psychres.2017.12.075
State	Published - Mar 2018

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2017.12.075

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title = "No differences in manic-like behaviors between voluntary ethanol and water drinking in Lateral Hypothalamic Kindled (LHK) alcohol preferring rats",

abstract = "This study investigates phenotypic differences of manic-like behaviors during voluntary ethanol (vs. water) intake in alcohol preferring (P) rats, using the lateral hypothalamus kindled (LHK) rat mania model. Alcohol preferring (P) rats exhibited classic manic-like behaviors during kindling and the post-kindling intervals in all coded behaviors (p < 0.0001), lending further validity to the lateral hypothalamus kindled rat as a useful model to study mania. However, there was no significant phenotypic difference between alcohol and water drinking alcohol preferring (P) rats.",

author = "Gawad, {Noha Abdel} and Khalid Mohamed and Choi, {Doo Sup} and Abulseoud, {Osama A.}",

note = "Funding Information: This work is supported by grant support from NIH/NCRR CTA KL2 (RR024151; OAA). ",

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doi = "10.1016/j.psychres.2017.12.075",

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AU - Mohamed, Khalid

AU - Choi, Doo Sup

AU - Abulseoud, Osama A.

N1 - Funding Information: This work is supported by grant support from NIH/NCRR CTA KL2 (RR024151; OAA).

PY - 2018/3

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AB - This study investigates phenotypic differences of manic-like behaviors during voluntary ethanol (vs. water) intake in alcohol preferring (P) rats, using the lateral hypothalamus kindled (LHK) rat mania model. Alcohol preferring (P) rats exhibited classic manic-like behaviors during kindling and the post-kindling intervals in all coded behaviors (p < 0.0001), lending further validity to the lateral hypothalamus kindled rat as a useful model to study mania. However, there was no significant phenotypic difference between alcohol and water drinking alcohol preferring (P) rats.

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No differences in manic-like behaviors between voluntary ethanol and water drinking in Lateral Hypothalamic Kindled (LHK) alcohol preferring rats

Abstract

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