No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease

Liana Fidani, Danielle Compton, John Hardy, Ronald C. Petersen, Eric Tangalos, Vassiliki Mirtsou, Antonis Goulas, Fabienne Wavrant De Vrieze

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropathologically confirmed subjects. In this report we have compared the distribution of the above polymorphism in an independent group of clinically diagnosed AD patients, including a subgroup where the disease was pathologically confirmed, and a spousal control group. No statistically significant differences emerged from this comparison. We conclude that LPL cannot be a major factor in pathogenesis of AD.

Original languageEnglish (US)
Pages (from-to)192-194
Number of pages3
JournalNeuroscience Letters
Volume322
Issue number3
DOIs
StatePublished - Apr 12 2002

Keywords

  • Alzheimer's disease
  • Genetics
  • Lipoprotein lipase
  • Polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

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