No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease

Liana Fidani; Danielle Compton; John Hardy; Ronald C. Petersen; Eric Tangalos; Vassiliki Mirtsou; Antonis Goulas; Fabienne Wavrant De Vrieze

doi:10.1016/S0304-3940(02)00098-8

No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease

Liana Fidani, Danielle Compton, John Hardy, Ronald C. Petersen, Eric Tangalos, Vassiliki Mirtsou, Antonis Goulas, Fabienne Wavrant De Vrieze

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropathologically confirmed subjects. In this report we have compared the distribution of the above polymorphism in an independent group of clinically diagnosed AD patients, including a subgroup where the disease was pathologically confirmed, and a spousal control group. No statistically significant differences emerged from this comparison. We conclude that LPL cannot be a major factor in pathogenesis of AD.

Original language	English (US)
Pages (from-to)	192-194
Number of pages	3
Journal	Neuroscience Letters
Volume	322
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(02)00098-8
State	Published - Apr 12 2002

Keywords

Alzheimer's disease
Genetics
Lipoprotein lipase
Polymorphism

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(02)00098-8

Cite this

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title = "No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease",

abstract = "Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropathologically confirmed subjects. In this report we have compared the distribution of the above polymorphism in an independent group of clinically diagnosed AD patients, including a subgroup where the disease was pathologically confirmed, and a spousal control group. No statistically significant differences emerged from this comparison. We conclude that LPL cannot be a major factor in pathogenesis of AD.",

keywords = "Alzheimer's disease, Genetics, Lipoprotein lipase, Polymorphism",

author = "Liana Fidani and Danielle Compton and John Hardy and Petersen, {Ronald C.} and Eric Tangalos and Vassiliki Mirtsou and Antonis Goulas and {Wavrant De Vrieze}, Fabienne",

note = "Funding Information: Supported by the Mayo Foundation and by the Mayo NIA/NIH Alzheimer Center.",

year = "2002",

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doi = "10.1016/S0304-3940(02)00098-8",

language = "English (US)",

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pages = "192--194",

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T1 - No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease

AU - Fidani, Liana

AU - Compton, Danielle

AU - Hardy, John

AU - Petersen, Ronald C.

AU - Tangalos, Eric

AU - Mirtsou, Vassiliki

AU - Goulas, Antonis

AU - Wavrant De Vrieze, Fabienne

N1 - Funding Information: Supported by the Mayo Foundation and by the Mayo NIA/NIH Alzheimer Center.

PY - 2002/4/12

Y1 - 2002/4/12

N2 - Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropathologically confirmed subjects. In this report we have compared the distribution of the above polymorphism in an independent group of clinically diagnosed AD patients, including a subgroup where the disease was pathologically confirmed, and a spousal control group. No statistically significant differences emerged from this comparison. We conclude that LPL cannot be a major factor in pathogenesis of AD.

AB - Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropathologically confirmed subjects. In this report we have compared the distribution of the above polymorphism in an independent group of clinically diagnosed AD patients, including a subgroup where the disease was pathologically confirmed, and a spousal control group. No statistically significant differences emerged from this comparison. We conclude that LPL cannot be a major factor in pathogenesis of AD.

KW - Alzheimer's disease

KW - Genetics

KW - Lipoprotein lipase

KW - Polymorphism

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JO - Neuroscience Letters

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No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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