No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Fabienne Wavrant-Devrièze, Varuni Rudrasingham, Jean Charles Lambert, Sumi Chakraverty, Patrick Kehoe, Richard Crook, Philippe Amouyel, William Wu, Peter Holmans, Francis Rice, Jordi Pérez-Tur, Bernard Frigard, John C. Morris, Stephanie Carty, Dominique Cottel, Nigel Tunstall, Simon Lovestone, Ronald C. Petersen, Marie Christine Chartier-Harlin, Alison GoateMichael J. Owen, Julie Williams, John Hardy

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalNeuroscience Letters
Volume262
Issue number2
DOIs
StatePublished - Mar 5 1999

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Genetics
  • α2-macroglobulin

ASJC Scopus subject areas

  • Neuroscience(all)

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    Wavrant-Devrièze, F., Rudrasingham, V., Lambert, J. C., Chakraverty, S., Kehoe, P., Crook, R., Amouyel, P., Wu, W., Holmans, P., Rice, F., Pérez-Tur, J., Frigard, B., Morris, J. C., Carty, S., Cottel, D., Tunstall, N., Lovestone, S., Petersen, R. C., Chartier-Harlin, M. C., ... Hardy, J. (1999). No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neuroscience Letters, 262(2), 137-139. https://doi.org/10.1016/S0304-3940(99)00035-X