No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Fabienne Wavrant-Devrièze, Varuni Rudrasingham, Jean Charles Lambert, Sumi Chakraverty, Patrick Kehoe, Richard Crook, Philippe Amouyel, William Wu, Peter Holmans, Francis Rice, Jordi Pérez-Tur, Bernard Frigard, John C. Morris, Stephanie Carty, Dominique Cottel, Nigel Tunstall, Simon Lovestone, Ronald C. Petersen, Marie Christine Chartier-Harlin, Alison GoateMichael J. Owen, Julie Williams, John Hardy

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalNeuroscience Letters
Volume262
Issue number2
DOIs
StatePublished - Mar 5 1999

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Genetics
  • α2-macroglobulin

ASJC Scopus subject areas

  • Neuroscience(all)

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