No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Fabienne Wavrant-Devrièze, Varuni Rudrasingham, Jean Charles Lambert, Sumi Chakraverty, Patrick Kehoe, Richard Crook, Philippe Amouyel, William Wu, Peter Holmans, Francis Rice, Jordi Pérez-Tur, Bernard Frigard, John C. Morris, Stephanie Carty, Dominique Cottel, Nigel Tunstall, Simon Lovestone, Ronald Carl Petersen, Marie Christine Chartier-Harlin, Alison GoateMichael J. Owen, Julie Williams, John Hardy

Research output: Contribution to journalArticle

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Abstract

Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalNeuroscience Letters
Volume262
Issue number2
DOIs
StatePublished - Mar 5 1999

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alpha-Macroglobulins
Alzheimer Disease
Macroglobulins
Genes
Case-Control Studies
Late Onset Disorders

Keywords

  • α2-macroglobulin
  • Alzheimer's disease
  • Apolipoprotein E
  • Genetics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wavrant-Devrièze, F., Rudrasingham, V., Lambert, J. C., Chakraverty, S., Kehoe, P., Crook, R., ... Hardy, J. (1999). No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neuroscience Letters, 262(2), 137-139. https://doi.org/10.1016/S0304-3940(99)00035-X

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. / Wavrant-Devrièze, Fabienne; Rudrasingham, Varuni; Lambert, Jean Charles; Chakraverty, Sumi; Kehoe, Patrick; Crook, Richard; Amouyel, Philippe; Wu, William; Holmans, Peter; Rice, Francis; Pérez-Tur, Jordi; Frigard, Bernard; Morris, John C.; Carty, Stephanie; Cottel, Dominique; Tunstall, Nigel; Lovestone, Simon; Petersen, Ronald Carl; Chartier-Harlin, Marie Christine; Goate, Alison; Owen, Michael J.; Williams, Julie; Hardy, John.

In: Neuroscience Letters, Vol. 262, No. 2, 05.03.1999, p. 137-139.

Research output: Contribution to journalArticle

Wavrant-Devrièze, F, Rudrasingham, V, Lambert, JC, Chakraverty, S, Kehoe, P, Crook, R, Amouyel, P, Wu, W, Holmans, P, Rice, F, Pérez-Tur, J, Frigard, B, Morris, JC, Carty, S, Cottel, D, Tunstall, N, Lovestone, S, Petersen, RC, Chartier-Harlin, MC, Goate, A, Owen, MJ, Williams, J & Hardy, J 1999, 'No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease', Neuroscience Letters, vol. 262, no. 2, pp. 137-139. https://doi.org/10.1016/S0304-3940(99)00035-X
Wavrant-Devrièze F, Rudrasingham V, Lambert JC, Chakraverty S, Kehoe P, Crook R et al. No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neuroscience Letters. 1999 Mar 5;262(2):137-139. https://doi.org/10.1016/S0304-3940(99)00035-X
Wavrant-Devrièze, Fabienne ; Rudrasingham, Varuni ; Lambert, Jean Charles ; Chakraverty, Sumi ; Kehoe, Patrick ; Crook, Richard ; Amouyel, Philippe ; Wu, William ; Holmans, Peter ; Rice, Francis ; Pérez-Tur, Jordi ; Frigard, Bernard ; Morris, John C. ; Carty, Stephanie ; Cottel, Dominique ; Tunstall, Nigel ; Lovestone, Simon ; Petersen, Ronald Carl ; Chartier-Harlin, Marie Christine ; Goate, Alison ; Owen, Michael J. ; Williams, Julie ; Hardy, John. / No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. In: Neuroscience Letters. 1999 ; Vol. 262, No. 2. pp. 137-139.
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