No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

Matt Baker; Daniel Graff-Radford; Fabienne Wavrant Devrièze; Neill Graff-Radford; Ronald C. Petersen; Emre Kokmen; Brad Boeve; Liisa Myllykangas; Tuomo Polvikoski; Raimo Sulkava; Auli Verkoniemmi; Pentti Tienari; Matti Haltia; John Hardy; Mike Hutton; Jordi Perez-Tur

doi:10.1016/S0304-3940(00)01057-0

No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

Matt Baker, Daniel Graff-Radford, Fabienne Wavrant Devrièze, Neill Graff-Radford, Ronald C. Petersen, Emre Kokmen, Brad Boeve, Liisa Myllykangas, Tuomo Polvikoski, Raimo Sulkava, Auli Verkoniemmi, Pentti Tienari, Matti Haltia, John Hardy, Mike Hutton, Jordi Perez-Tur

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35 Scopus citations

Abstract

We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	147-149
Number of pages	3
Journal	Neuroscience Letters
Volume	285
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(00)01057-0
State	Published - May 12 2000

Keywords

Alzheimer's disease, Genetics
Progressive supranuclear palsy
TAU

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(00)01057-0

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Baker, M., Graff-Radford, D., Wavrant Devrièze, F., Graff-Radford, N., Petersen, R. C., Kokmen, E., Boeve, B., Myllykangas, L., Polvikoski, T., Sulkava, R., Verkoniemmi, A., Tienari, P., Haltia, M., Hardy, J., Hutton, M., & Perez-Tur, J. (2000). No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease. Neuroscience Letters, 285(2), 147-149. https://doi.org/10.1016/S0304-3940(00)01057-0

Baker, M, Graff-Radford, D, Wavrant Devrièze, F, Graff-Radford, N , Petersen, RC, Kokmen, E, Boeve, B, Myllykangas, L, Polvikoski, T, Sulkava, R, Verkoniemmi, A, Tienari, P, Haltia, M, Hardy, J, Hutton, M & Perez-Tur, J 2000, 'No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease', Neuroscience Letters, vol. 285, no. 2, pp. 147-149. https://doi.org/10.1016/S0304-3940(00)01057-0

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abstract = "We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event. (C) 2000 Elsevier Science Ireland Ltd.",

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author = "Matt Baker and Daniel Graff-Radford and {Wavrant Devri{\`e}ze}, Fabienne and Neill Graff-Radford and Petersen, {Ronald C.} and Emre Kokmen and Brad Boeve and Liisa Myllykangas and Tuomo Polvikoski and Raimo Sulkava and Auli Verkoniemmi and Pentti Tienari and Matti Haltia and John Hardy and Mike Hutton and Jordi Perez-Tur",

note = "Funding Information: The sibpair samples used in this study were selected from those collected by the NIMH Alzheimer's Genetics Initiative and were banked at the Coriell Cell Repository or from the NIA Cell bank (Indiana University). The collection of the Finnish samples were supported by the Alzheimer Foundation of Finland, the Emil Aaltonen Foundation, the Helsingin Sanomat Centennial Foundation, the Foundation of Signe and Anu Gyllenberg, the Medical Council of the Finnish Academy, the Sigrid Juselius Foundation, the University of Helsinki and the Helsinki University Central Hospital. The collection of the Mayo series was supported by the Mayo ADRC grant (NIH). Genotyping and data analysis were supported by a grant from the MRC (UK), the Alzheimer's Association, the Metropolitan Life Foundation, the Mayo Foundation and the NIH (J.H., M.H.).",

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doi = "10.1016/S0304-3940(00)01057-0",

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AU - Petersen, Ronald C.

AU - Kokmen, Emre

AU - Boeve, Brad

AU - Myllykangas, Liisa

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AU - Sulkava, Raimo

AU - Verkoniemmi, Auli

AU - Tienari, Pentti

AU - Haltia, Matti

AU - Hardy, John

AU - Hutton, Mike

AU - Perez-Tur, Jordi

N1 - Funding Information: The sibpair samples used in this study were selected from those collected by the NIMH Alzheimer's Genetics Initiative and were banked at the Coriell Cell Repository or from the NIA Cell bank (Indiana University). The collection of the Finnish samples were supported by the Alzheimer Foundation of Finland, the Emil Aaltonen Foundation, the Helsingin Sanomat Centennial Foundation, the Foundation of Signe and Anu Gyllenberg, the Medical Council of the Finnish Academy, the Sigrid Juselius Foundation, the University of Helsinki and the Helsinki University Central Hospital. The collection of the Mayo series was supported by the Mayo ADRC grant (NIH). Genotyping and data analysis were supported by a grant from the MRC (UK), the Alzheimer's Association, the Metropolitan Life Foundation, the Mayo Foundation and the NIH (J.H., M.H.).

PY - 2000/5/12

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N2 - We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event. (C) 2000 Elsevier Science Ireland Ltd.

AB - We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event. (C) 2000 Elsevier Science Ireland Ltd.

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No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

Abstract

Keywords

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