No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

Matt Baker, Daniel Graff-Radford, Fabienne Wavrant Devrièze, Neill Graff-Radford, Ronald C. Petersen, Emre Kokmen, Brad Boeve, Liisa Myllykangas, Tuomo Polvikoski, Raimo Sulkava, Auli Verkoniemmi, Pentti Tienari, Matti Haltia, John Hardy, Mike Hutton, Jordi Perez-Tur

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)147-149
Number of pages3
JournalNeuroscience Letters
Volume285
Issue number2
DOIs
StatePublished - May 12 2000

Keywords

  • Alzheimer's disease, Genetics
  • Progressive supranuclear palsy
  • TAU

ASJC Scopus subject areas

  • Neuroscience(all)

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    Baker, M., Graff-Radford, D., Wavrant Devrièze, F., Graff-Radford, N., Petersen, R. C., Kokmen, E., Boeve, B., Myllykangas, L., Polvikoski, T., Sulkava, R., Verkoniemmi, A., Tienari, P., Haltia, M., Hardy, J., Hutton, M., & Perez-Tur, J. (2000). No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease. Neuroscience Letters, 285(2), 147-149. https://doi.org/10.1016/S0304-3940(00)01057-0