TY - JOUR
T1 - No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
AU - Goode, Ellen L.
AU - Szabo, Csilla
AU - Prokunina-Olsson, Ludmila
AU - Vierkant, Robert A.
AU - Fredericksen, Zachary S.
AU - Collins, Francis S.
AU - White, Kristin L.
AU - Schmidt, Michele
AU - Fridley, Brooke L.
AU - Couch, Fergus J.
N1 - Funding Information:
This work was supported, in part, by funding from the Mayo foundation and R01 CA122443.
PY - 2009/9/4
Y1 - 2009/9/4
N2 - Background: TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods: Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results: No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion: Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed.
AB - Background: TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods: Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results: No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion: Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed.
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U2 - 10.1186/1471-2407-9-312
DO - 10.1186/1471-2407-9-312
M3 - Article
C2 - 19732438
AN - SCOPUS:70349850357
SN - 1471-2407
VL - 9
SP - 312
JO - BMC cancer
JF - BMC cancer
M1 - 312
ER -