NMR microscopy of tissue in organic and mixed solvents

Slobodan Macura, Prasanna K. Mishra, Jeffrey D. Gamez, Istvan Pirko

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The use organic and mixed solvents for nuclear magnetic resonance microscopy of fixed tissue is proposed as a means for improving image information content. NMR properties of some standard solvents (methanol, acetone or DMSO) and solvents in use for tissue processing in pathology (xylenes, paraffin, "Clearify") have been measured, reviewed and analyzed. It was found that DMSO and paraffin are very useful solvents that provide images of better quality than those obtained in water (neutralized formalin buffer). This is illustrated on formalin-fixed mouse brain sections imaged at 16.4 T (700 MHz).

Original languageEnglish (US)
Pages (from-to)1641-1654
Number of pages14
JournalJournal of the Serbian Chemical Society
Volume78
Issue number11
DOIs
StatePublished - Nov 27 2013

Keywords

  • Cross-relaxation
  • MRI
  • MRM
  • Magnetization transfer
  • NMR
  • NMR imaging
  • NMR microscopy
  • Nuclear magnetic resonance

ASJC Scopus subject areas

  • Chemistry(all)

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