Abstract
Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the clearance of central nervous system viral infections has not been explored. Using the Theiler's murine encephalomyelitis virus model, the authors found that NKG2D-positive CD8+ cytotoxic T cells enter the brain, that NKG2D ligands are expressed in the brain during acute infection, and that interruption of NKG2D ligand recognition via treatment with a function-blocking antibody attenuates the efficacy of viral clearance from the central nervous system.
Original language | English (US) |
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Pages (from-to) | 261-266 |
Number of pages | 6 |
Journal | Journal of neurovirology |
Volume | 14 |
Issue number | 3 |
DOIs | |
State | Published - May 2008 |
Keywords
- Cytotoxic T cell
- Enterovirus
- H60
- Mult1
- Neurovirulence
- Rae1
- TMEV
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Virology