NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain

Chandra Deb, Charles L. Howe

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the clearance of central nervous system viral infections has not been explored. Using the Theiler's murine encephalomyelitis virus model, the authors found that NKG2D-positive CD8+ cytotoxic T cells enter the brain, that NKG2D ligands are expressed in the brain during acute infection, and that interruption of NKG2D ligand recognition via treatment with a function-blocking antibody attenuates the efficacy of viral clearance from the central nervous system.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalJournal of neurovirology
Volume14
Issue number3
DOIs
StatePublished - May 2008

Keywords

  • Cytotoxic T cell
  • Enterovirus
  • H60
  • Mult1
  • Neurovirulence
  • Rae1
  • TMEV

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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