Nitrosyl haemoglobin: The no-spin as a relaxation probe in the solvent-proton magnetic resonance experiment demonstrating the phosphate-induced widening of the haem-pocket

B. Benko, S. Vuk-Pavlović

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Abstract

This communication presents evidence that nitric oxide bound to ferrous haem-iron of haemoglobin is a powerful relaxation probe in the solvent-proton magnetic resonance experiments. When such an experiment is applied to the interaction of human haemoglobin with inositol hexaphosphate, it shows that phosphate increases the solvent-dynamics in the haem-pockets, consistent with their widening. Some implications of these findings are discussed here.

Original languageEnglish (US)
Pages (from-to)1303-1307
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume71
Issue number4
DOIs
StatePublished - Aug 23 1976

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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