This communication presents evidence that nitric oxide bound to ferrous haem-iron of haemoglobin is a powerful relaxation probe in the solvent-proton magnetic resonance experiments. When such an experiment is applied to the interaction of human haemoglobin with inositol hexaphosphate, it shows that phosphate increases the solvent-dynamics in the haem-pockets, consistent with their widening. Some implications of these findings are discussed here.
|Original language||English (US)|
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Aug 23 1976|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology