TY - JOUR
T1 - Nitrofurantoin and Minocycline-Associated Vasculitic Neuropathy
T2 - Case Reports and Literature Review
AU - Aladawi, Mohammad
AU - Shelly, Shahar
AU - Dyck, P. James B.
AU - Koster, Matthew
AU - Engelstad, Janean
AU - Piccione, Ezequiel A.
AU - Naddaf, Elie
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Background:Vasculitic neuropathies usually present acutely to subacutely, with an asymmetric pattern, involving multiple peripheral nerve territories. Drug-induced vasculitis is an often overlooked etiology of vasculitic neuropathy.Methods:We present the first reported case of nitrofurantoin-associated and an illustrative case of minocycline-associated vasculitic neuropathy, with a review of the literature.Results:The first patient is a 60-year-old woman who developed axonal sensorimotor peripheral neuropathy after nitrofurantoin use, with a superficial radial nerve biopsy confirming vasculitis. The second patient is a 23-year-old woman, with a history of acne vulgaris treated with minocycline, who presented with a subacute right common peroneal mononeuropathy followed by a left deep peroneal mononeuropathy, with elevated antinuclear, perinuclear-antineutrophil cytoplasmic, and myleoperoxidase antibodies, and MPO titers, and a sural nerve biopsy showing large arteriole vasculitis. Finally, we provide a comprehensive review of previously published cases.Conclusions:Medications should be considered as a trigger for medication-induced vasculitic neuropathy. Accurate diagnosis would ensure timely treatment.
AB - Background:Vasculitic neuropathies usually present acutely to subacutely, with an asymmetric pattern, involving multiple peripheral nerve territories. Drug-induced vasculitis is an often overlooked etiology of vasculitic neuropathy.Methods:We present the first reported case of nitrofurantoin-associated and an illustrative case of minocycline-associated vasculitic neuropathy, with a review of the literature.Results:The first patient is a 60-year-old woman who developed axonal sensorimotor peripheral neuropathy after nitrofurantoin use, with a superficial radial nerve biopsy confirming vasculitis. The second patient is a 23-year-old woman, with a history of acne vulgaris treated with minocycline, who presented with a subacute right common peroneal mononeuropathy followed by a left deep peroneal mononeuropathy, with elevated antinuclear, perinuclear-antineutrophil cytoplasmic, and myleoperoxidase antibodies, and MPO titers, and a sural nerve biopsy showing large arteriole vasculitis. Finally, we provide a comprehensive review of previously published cases.Conclusions:Medications should be considered as a trigger for medication-induced vasculitic neuropathy. Accurate diagnosis would ensure timely treatment.
KW - drug-induced vasculitis
KW - minocycline
KW - nitrofurantoin
KW - peripheral neuropathy
KW - vasculitic neuropathy
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U2 - 10.1097/CND.0000000000000404
DO - 10.1097/CND.0000000000000404
M3 - Review article
C2 - 36409339
AN - SCOPUS:85142388390
SN - 1522-0443
VL - 24
SP - 85
EP - 94
JO - Journal of clinical neuromuscular disease
JF - Journal of clinical neuromuscular disease
IS - 2
ER -