Nitric oxide

What role does it play in inflammation and tissue destruction

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Large amounts of nitric oxide (NO) are produced at sites of inflammation through the action of inducible nitric oxide synthase (iNOS) present in both infiltrating leucocytes and activated, resident tissue cells. However, the role of NO in inflammation remains unclear. NO is a vasodilator, which inhibits the adhesion of neutrophils to the vascular endothelium; it reduces the production of IL-6 by Kupffer cells and chondrocytes, and the production of gamma-IFN and TNF-α by splenocytes. The literature provides contradictory information on the effect of NO on vascular leakiness, chemotaxis, prostaglandin production and tissue damage. Increasingly, data suggest that NO is immunosuppressive. Inhibitors of NOS have potent prophylactic activity in several but not all, animal models of inflammatory disease. However, in rat adjuvant arthritis, therapeutic activity is weak. Whether inhibitors of iNOS will be therapeutically useful in human inflammatory diseases cannot be predicted on the basis of present information.

Original languageEnglish (US)
Pages (from-to)107-116
Number of pages10
JournalAgents and Actions Supplements
Volume47
StatePublished - 1995
Externally publishedYes

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Nitric Oxide
Inflammation
Nitric Oxide Synthase Type II
Animal Disease Models
Experimental Arthritis
Kupffer Cells
Vascular Endothelium
Chemotaxis
Immunosuppressive Agents
Chondrocytes
Vasodilator Agents
Prostaglandins
Blood Vessels
Interleukin-6
Neutrophils
Leukocytes
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Nitric oxide : What role does it play in inflammation and tissue destruction. / Evans, Christopher H.

In: Agents and Actions Supplements, Vol. 47, 1995, p. 107-116.

Research output: Contribution to journalArticle

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