Nitric Oxide in Gastrointestinal Health and Disease

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203 Scopus citations

Abstract

Nitric oxide is an intracellular and intercellular messenger with important functions in a number of physiologic and pathobiologic processes within gastroenterology and hepatology, including gastrointestinal tract motility, mucosal function, inflammatory responses, gastrointestinal malignancy, and blood flow regulation. Since the broad review of this topic in GASTROENTEROLOGY more than 10 years ago, a number of advances have been made in the area of NO biology and its relevance to the gastrointestinal system. The aim of this review is to focus on our expanded understanding of the role NO plays in human gastrointestinal and hepatic physiology and disease processes by drawing on data from relevant in vitro and animal models as well as observational human studies.

Original languageEnglish (US)
Pages (from-to)903-913
Number of pages11
JournalGastroenterology
Volume126
Issue number3
DOIs
StatePublished - Mar 2004

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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