Nitric oxide in arthritis

Christopher H Evans, M. Stefanovic-Racic

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Although arthritis occurs in many different forms, loss of articular cartilage and joint inflammation are the predominant pathophysiological processes consistently present in this group of diseases. Depending upon the particular arthritide, these two pathologies may take place together or separately. Evidence is accumulating to suggest that NO is produced locally within human osteoarthritic and rheumatoid joints. The articular chondrocytes and, perhaps, infiltrating leukocytes appear to be the major intraarticular sources of NO. All published data agree that biosynthesis of NO increases in animal models of rheumatoid arthritis, and inhibitors of NO synthases show strong prophylactic, anti-inflammatory activity. However, one study suggests that therapeutic activity may be weak. Chondrocytes produce large amounts of NO after exposure to interleukin-1 (IL-1). In rabbit, human and rat, but not bovine, articular cartilage endogenously produced NO inhibits the biosynthesis of matrix proteoglycans. However, studies with bovine articular cartilage further indicate that NO partially protects proteoglycans from degradation in response to IL-1. These data encourage the notion that NO is involved in the pathophysiology of arthritis, but caution that this involvement may be complex.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalMethods: A Companion to Methods in Enzymology
Volume10
Issue number1
DOIs
StatePublished - Aug 1996
Externally publishedYes

Fingerprint

Cartilage
Articular Cartilage
Arthritis
Nitric Oxide
Joints
Biosynthesis
Proteoglycans
Chondrocytes
Interleukin-1
Pathology
Nitric Oxide Synthase
Rats
Rheumatoid Arthritis
Animals
Leukocytes
Anti-Inflammatory Agents
Animal Models
Rabbits
Inflammation
Degradation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Molecular Biology

Cite this

Nitric oxide in arthritis. / Evans, Christopher H; Stefanovic-Racic, M.

In: Methods: A Companion to Methods in Enzymology, Vol. 10, No. 1, 08.1996, p. 38-42.

Research output: Contribution to journalArticle

Evans, Christopher H ; Stefanovic-Racic, M. / Nitric oxide in arthritis. In: Methods: A Companion to Methods in Enzymology. 1996 ; Vol. 10, No. 1. pp. 38-42.
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