Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension

R. Pedrinelli, F. M. Fouad, R. C. Tarazi, E. L. Bravo, Stephen C Textor

Research output: Contribution to journalArticle

Abstract

Thirteen patients with hypertension and normal renal function received nitrendipine, a calcium entry blocker. Nitrendipine did not modify renal blood flow (RBF) or glomerular filtration rate (GFR), decreased mean arterial pressure (MAP) and total peripheral resistance, and did not significantly change cardiac output. Individual RBF changes did not correlate with MAP or cardiac output modifications. Mean arterial pressure changes were inversely correlated with basal renin levels and directly associated with age. Plasma catecholamines and plasma renin activity increased, but plasma aldosterone and plasma volume did not change significantly. However, the greater decrements of MAP tended to be associated with the greater increases in plasma volume. Data show that long-term calcium entry blockade by nitrendipine does not modify RBF or GFR despite the decreased renal perfusion pressure. Further, nitrendipine may be more effective in older patients and the presence of low renin.

Original languageEnglish (US)
Pages (from-to)62-65
Number of pages4
JournalArchives of Internal Medicine
Volume146
Issue number1
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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