Abstract
• Thirteen patients with hypertension and normal renal function received nitrendipine, a calcium entry blocker. Nitrendipine did not modify renal blood flow (RBF) or glomerular filtration rate (GFR), decreased mean arterial pressure (MAP) and total peripheral resistance, and did not significantly change cardiac output. Individual RBF changes did not correlate with MAP or cardiac output modifications. Mean arterial pressure changes were inversely correlated with basal renin levels and directly associated with age. Plasma catecholamines and plasma renin activity increased, but plasma aldosterone and plasma volume did not change significantly. However, the greater decrements of MAP tended to be associated with the greater increases in plasma volume. Data show that long-term calcium entry blockade by nitrendipine does not modify RBF or GFR despite the decreased renal perfusion pressure. Further, nitrendipine may be more effective in older patients and the presence of low renin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62-65 |
| Number of pages | 4 |
| Journal | Archives of Internal Medicine |
| Volume | 146 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
Cite this
Nitrendipine, a Calcium-Entry Blocker : Renal and Humoral Effects in Human Arterial Hypertension. / Pedrinelli, Roberto; Fouad, Fetnat M.; Tarazi, Robert C.; Bravo, Emmanuel L.; Textor, Stephen C.
In: Archives of Internal Medicine, Vol. 146, No. 1, 1986, p. 62-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nitrendipine, a Calcium-Entry Blocker
T2 - Renal and Humoral Effects in Human Arterial Hypertension
AU - Pedrinelli, Roberto
AU - Fouad, Fetnat M.
AU - Tarazi, Robert C.
AU - Bravo, Emmanuel L.
AU - Textor, Stephen C
PY - 1986
Y1 - 1986
N2 - • Thirteen patients with hypertension and normal renal function received nitrendipine, a calcium entry blocker. Nitrendipine did not modify renal blood flow (RBF) or glomerular filtration rate (GFR), decreased mean arterial pressure (MAP) and total peripheral resistance, and did not significantly change cardiac output. Individual RBF changes did not correlate with MAP or cardiac output modifications. Mean arterial pressure changes were inversely correlated with basal renin levels and directly associated with age. Plasma catecholamines and plasma renin activity increased, but plasma aldosterone and plasma volume did not change significantly. However, the greater decrements of MAP tended to be associated with the greater increases in plasma volume. Data show that long-term calcium entry blockade by nitrendipine does not modify RBF or GFR despite the decreased renal perfusion pressure. Further, nitrendipine may be more effective in older patients and the presence of low renin.
AB - • Thirteen patients with hypertension and normal renal function received nitrendipine, a calcium entry blocker. Nitrendipine did not modify renal blood flow (RBF) or glomerular filtration rate (GFR), decreased mean arterial pressure (MAP) and total peripheral resistance, and did not significantly change cardiac output. Individual RBF changes did not correlate with MAP or cardiac output modifications. Mean arterial pressure changes were inversely correlated with basal renin levels and directly associated with age. Plasma catecholamines and plasma renin activity increased, but plasma aldosterone and plasma volume did not change significantly. However, the greater decrements of MAP tended to be associated with the greater increases in plasma volume. Data show that long-term calcium entry blockade by nitrendipine does not modify RBF or GFR despite the decreased renal perfusion pressure. Further, nitrendipine may be more effective in older patients and the presence of low renin.
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U2 - 10.1001/archinte.1986.00360130072010
DO - 10.1001/archinte.1986.00360130072010
M3 - Article
C2 - 2935106
AN - SCOPUS:84941816335
VL - 146
SP - 62
EP - 65
JO - JAMA Internal Medicine
JF - JAMA Internal Medicine
SN - 2168-6106
IS - 1
ER -